Laboratory Investigation

FIGURE 2

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Differentially Expressed Genes in Two LNCaP Prostate Cancer Cell Lines Reflecting Changes during Prostate Cancer Progression

Markku H Vaarala, Katja Porvari, Atte Kyllönen and Pirkko Vihko

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Figure 2.

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In situ hybridization of overexpressed genes in LNCaP+ and LNCaP- cells. MAOA, EST AA781244, and fatty acid-binding protein 5 were expressed in both benign (a, e, and k, respectively) and malignant (b, f, and l, respectively) epithelium of human prostate. Expression of the EST similar to rat P044 was weak, but still detectable in epithelium of BPH (c) and prostate cancer (d). EST AA412049 tended to be slightly more highly expressed in benign epithelial cells (g) compared with malignant epithelium (h). The EST similar to galectin-1 was expressed in the stroma of both BPH and prostate cancer samples (i and j, respectively). Hematoxylin and eosin staining. Black vertical bar in right upper corner of a corresponds to 50 mum for all panels.

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