Laboratory Investigation

FIGURE 1

FROM:

Down-Regulation of Renal Endothelial Nitric Oxide Synthase Expression in Experimental Glomerular Thrombotic Microangiopathy

Xin J Zhou, Zoltan Laszik, Zhenmin Ni, Xiu Q Wang, Daniel J Brackett, Megan R Lerner, Fred G Silva and Nosratola D Vaziri

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Figure 1.

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Glomerular thrombotic microangiography (TMA). (a) A representative glomerulus reveals extensive capillary thrombi (arrows) in a rat killed 180 minutes after endotoxin administration (trichrome stains, original magnification, times 400). (b) Direct immunofluorescence with an antibody to fibrinogen shows immunoreactive glomerular intracapillary thrombi in the same animal (original magnification, times 400). (c) A representative electron photomicrograph shows a portion of a glomerular capillary loop occluded by electron-dense fibrillary material corresponding to fibrin (arrows). Prominent accumulation of platelets (triangles) along the inner surface of the glomerular capillary endothelium is also seen. Curved arrow indicates the glomerular basement membrane (times 9,000).

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