Laboratory Investigation - Figures and tables for article: Docosahexaenoic Acid Deficit Is Not a Major Pathogenic Factor in Peroxisome-Deficient Mice

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Docosahexaenoic Acid Deficit Is Not a Major Pathogenic Factor in Peroxisome-Deficient Mice

A Janssen, M Baes, P Gressens, G P Mannaerts, P Declercq and P P Van Veldhoven

Figure 1.

GC analysis of long chain fatty acids in brain. Transmethylated fatty acids from the brain phospholipids of a PEX5^-/- mouse (a) and of a PEX5^+/+ mouse (b) were separated on a BPX70 column. The FID response during 15 and 30 minutes is shown. As described in "Materials and Methods," the temperature at 15 minutes was 181° C and the temperature gradient was 3° C/minute. The numbered peaks correspond to the following compounds: 1, C20:4n-6; 2, C22:6n-3; 3, C26:0; and 4, C24:6n-3. IS represents the internal standard C27:0.

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Figure 2.

DHA content of the brain and liver phospholipids. Brain and liver of PEX5^-/- pups (open bars) and control pups (PEX5^+/- and PEX5^+/+) (closed bars) from untreated and DHA-EE–treated mothers were extracted, and DHA was quantified in the phospholipid fraction. The data are presented as mean plusminus sd. Statistical analysis was done by one-way ANOVA. * Significantly different from control; ** significantly different from untreated PEX5^-/- brain.

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Figure 3.

Neuronal migration defect in PEX5^-/- mice. Sections of the cortex of newborn mice were stained with cresylviolet. (a) PEX5^-/-, untreated; (b) PEX5^-/-, DHA-EE treated; (c) PEX5^+/+, untreated. Magnification bar is 40 m.

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Table 1 - VLCFA and Plasmalogens in the Brain of Newborn Zellweger and Control Mice.

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FIGURES AND TABLES

Docosahexaenoic Acid Deficit Is Not a Major Pathogenic Factor in Peroxisome-Deficient Mice

Figure 1.

Figure 2.

Figure 3.

Table 1 - VLCFA and Plasmalogens in the Brain of Newborn Zellweger and Control Mice.