Browse Articles

  • Article |

    In this paper, the authors found that conditional ablation of Shp2 in mouse K14-positive corneal epithelium (Shp2K14ce-cko) impairs corneal innervation and results in corneal epithelial thinning, which resembles neurotrophic keratopathy. Furthermore, the data indicate that Shp2 signaling plays a pivotal role in corneal epithelial homeostasis.

    • Yuka Okada
    • , Yujin Zhang
    • , Lingling Zhang
    • , Lung-Kun Yeh
    • , Yen-Chiao Wang
    • , Shizuya Saika
    •  & Chia-Yang Liu
  • Review Article |

    Transient receptor ion channels have emerged as critical channels/receptors in numerous physiological and pathological conditions. In this paper the authors discuss our current understanding of the role of macrophage transient receptor potential channel subfamily V member 4 (TRPV4) in various inflammatory conditions.

    • Bidisha Dutta
    • , Rakesh K. Arya
    • , Rishov Goswami
    • , Mazen O. Alharbi
    • , Shweta Sharma
    •  & Shaik O. Rahaman
  • Article |

    Polydatin (PD) protects against LPS-induced vascular leakage in multiple organs and this effect is dependent on SIRT3 activation. PD enhances SIRT3-mediated deacetylation of SOD2 and CypD, thus suppressing mitochondrial dysfunction and subsequent endothelial barrier dysfunction. In addition, RAGE is involved in LPS-regulated SIRT3 signaling.

    • Jie Wu
    • , Zhiya Deng
    • , Maomao Sun
    • , Weijin Zhang
    • , Yang Yang
    • , Zhenhua Zeng
    • , Jianhua Wu
    • , Qin Zhang
    • , Yanan Liu
    • , Zhenfeng Chen
    • , Xiaohua Guo
    • , Ke-seng Zhao
    • , Qiaobing Huang
    •  & Zhongqing Chen
  • Article |

    The authors reveal that TRPV4, a thermosensitive ion channel, is constitutively active in the brain. They found that local brain temperature is increased at epileptogenic foci, and that hyperthermia lead TRPV4 over-activation and hyper-neuronal activities. Notably, brain cooling treatment drastically suppresses epileptic discharges dependent on the inactivation of TRPV4.

    • Koji Shibasaki
    • , Katsuya Yamada
    • , Hideki Miwa
    • , Yuchio Yanagawa
    • , Michiyasu Suzuki
    • , Makoto Tominaga
    •  & Yasuki Ishizaki
  • Article |

    The authors investigated the potential mechanisms of interleukin-33 (IL-33) in the pathogenesis of ulcerative colitis. IL-33 was found to sustain mucosal inflammation by down-regulation of protective ABCG5/8 during recovery from colitis. These results may help to increase understanding regarding the IL-33-mediated pathogenesis of ulcerative colitis and potentially contribute to creation of a novel therapeutic strategy.

    • Yoshiyuki Mishima
    • , Hiroki Sonoyama
    • , Shunji Ishihara
    • , Naoki Oshima
    • , Ichiro Moriyama
    • , Kousaku Kawashima
    •  & Yoshikazu Kinoshita
  • Technical Report
    | Open Access

    Digital image analysis (DIA) of multiplex fluorescence-based immunohistochemistry and visual chromogenic evaluation of CDX2, SOX2, SOX9, E-cadherin, and β-catenin in colorectal cancer are comparable, recognizing prognostic value of CDX2 and negative correlation with SOX2. Membrane staining is best evaluated visually, while DIA enables single-cell coexpression analysis and improves visualization and detection of clinicopathological and biological associations.

    • Nair Lopes
    • , Christian Holst Bergsland
    • , Merete Bjørnslett
    • , Teijo Pellinen
    • , Aud Svindland
    • , Arild Nesbakken
    • , Raquel Almeida
    • , Ragnhild A. Lothe
    • , Leonor David
    •  & Jarle Bruun
  • Article |

    High expression of the transcription factor ETS2 plays important role in a mouse model of renal fibrosis and in TGF-β1-treated human tubular epithelial cells (HK2). ETS2 promotes TGF-β1-induces epithelial-to-mesenchymal transition (EMT) phenotypic inversion and the expression of EMT markers in HK2 cells by enhancing transcription of JUNB. These findings suggest that ETS2 could be a novel target for the prevention the progression of renal fibrosis.

    • Fang Yao
    • , Xiaojing Wang
    • , Zhong-Kai Cui
    • , Haibing Lan
    • , Xiaolan Ai
    • , Qiancheng Song
    • , Zhenguo Chen
    • , Jun Yang
    • , Bingyi Wu
    •  & Xiaochun Bai
  • Technical Report |

    The authors designed an adapter multiplex PCR amplicon with multiple domain melting curves to rapidly detect and genotype at least 20 ALK fusion variants in one tube with HRM. In addition, they introduced feature extraction of the second derivative curve to assist visual analysis to automatically discriminate ALK fusion variants.

    • Mei Li
    • , Shen Lu
    •  & Xu Sun
  • Article |

    The expression of HIP/PAP and its mouse counterpart, Reg3B, is markedly unregulated in fibrotic livers. Ectopic HIP/PAP potently protects from CCl4- and BDL-induced liver fibrosis in mice. This study shows that downregulation of TGF-βRII expression is one of the important underlying mechanisms for HIP/PAP in suppression of hepatic fibrosis.

    • Qian Li
    • , Hanchao Li
    • , Yifei Lv
    • , Qiannan Zhang
    • , Xueting Zhang
    • , Shuang Li
    • , Xiaoyan Zheng
    • , Yanhua Wang
    •  & Zhiming Hao
  • Technical Report |

    The authors examined the capability of propagation-based phase-contrast tomography (PB-PCT) with single-distance phase retrieval for longitudinal in vivo monitoring of bone changes using monochromatic synchrotron light. The application of PB-PCT to the measurement of bone defect healing in mice demonstrated its potential for tracking volumetric and mineral-density changes in newly formed bone.

    • Takeshi Matsumoto
    • , Ryota Shimizu
    •  & Kentaro Uesugi
  • Article |

    The two Na+ and water pore-forming claudins, claudin-2 and claudin-15, are reciprocally regulated during human development. This study shows that expression of these claudins is altered in celiac disease, graft-versus-host disease, and common variable immunodeficiency, but that the specific claudin affected differed between children and adults, suggesting distinct contributions to diarrheal pathophysiology.

    • M. Lora D. M. Ong
    • , Sunil Yeruva
    • , Anne Sailer
    • , Steven P. Nilsen
    •  & Jerrold R. Turner
  • Article |

    Most of the cancer-associated genes mutated only in high-grade gastrointestinal stromal tumors (GISTs) are mainly involved in cell cycle control. High-grade GISTs had more MYC copy number gains than matched low-grade tumors. The authors show that alterations in cell cycle regulation-associated genes, may promote primary progression from low-grade GISTs to high-grade tumors by regulating tumor cell proliferation.

    • Peifeng Li
    • , Mingyang Li
    • , Kaijing Wang
    • , Yixiong Liu
    • , Yingmei Wang
    • , Danhui Zhao
    • , Jia Chai
    • , Jing Ma
    • , Xia Li
    • , Jie Wei
    • , Linni Fan
    • , Feng Zhang
    • , Jing Ye
    • , Qingguo Yan
    • , Shuangping Guo
    •  & Zhe Wang
  • Article |

    The authors provide an in-depth explanation of how HO-1 activation, through PI3K/Akt pathway, protects the lung from oxidative injury in the setting of sepsis by regulating mitochondrial quality control. This study presents a rationale for developing HO-1 therapy to prevent sepsis-related lung injury.

    • Jia Shi
    • , Jianbo Yu
    • , Yuan Zhang
    • , Lili Wu
    • , Shuan Dong
    • , Lina Wu
    • , Lingzhi Wu
    • , Shihan Du
    • , Yanfang Zhang
    •  & Daqing Ma
  • Article
    | Open Access

    While the transcription factor TBX3 is widely studied in tumorigenesis, the functionality of the two isoforms (TBX3iso1 and TBX3iso2) which differ in their DNA-binding domain is not well understood. By utilizing a nude mouse xenograft model, the authors identified differential tumorigenic potential between TBX3 isoforms, with TBX3iso1 (but not TBX3iso2) promoting invasive carcinoma in vivo through induction of angiogenesis. This process is moderated by downstream mediators osteopontin (OPN) and hyaluronan synthase 2 (HAS2).

    • Milica Krstic
    • , Haider M. Hassan
    • , Bart Kolendowski
    • , M. Nicole Hague
    • , Pieter. H. Anborgh
    • , Carl O. Postenka
    • , Joseph Torchia
    • , Ann F. Chambers
    •  & Alan B. Tuck
  • Article
    | Open Access

    The endocannabinoid (EC) system has been implicated in the pathogenesis nonalcoholic fatty liver diseases (NAFLD). Here the authors demonstrate that endocannabinoid receptor 1 (CB1) receptor knockout in vivo and pharmacologic antagonization of CB1 in cell culture decreases expression of lipid droplet binding protein perilipin 2, which might be an essential step in lipid breakdown. Thus, pharmacologic modulation of the CB1-perilipin 2 axis might represent a novel therapeutic approach for the treatment of steatosis.

    • Karuna Irungbam
    • , Yuri Churin
    • , Tomomitsu Matono
    • , Jakob Weglage
    • , Matthias Ocker
    • , Dieter Glebe
    • , Martin Hardt
    • , Alica Koeppel
    • , Martin Roderfeld
    •  & Elke Roeb
  • Technical Report |

    Bone marrow aspirate (BMA) differential cell counts (DCCs) are critical for classification of hematologic disorders. Manual DCCs are still considered the gold standard as a reliable automated method is yet to be developed. Digital pathology and machine learning represent a highly promising technology for this purpose. The authors report their experience developing machine learning algorithms to detect and classify BMA cells. Promising early results signify an important initial step in the effort to devise a reliable, objective method to automate DCCs.

    • Ramraj Chandradevan
    • , Ahmed A. Aljudi
    • , Bradley R. Drumheller
    • , Nilakshan Kunananthaseelan
    • , Mohamed Amgad
    • , David A. Gutman
    • , Lee A. D. Cooper
    •  & David L. Jaye
  • Article |

    This study suggests a potential mechanism wherein microRNA-21-5p (miR-21-5p) inhibition downregulates autophagy, migration ability, and LC3B expression via PTEN/AKT signaling in electron beam (EB)-irradiated keloid fibroblasts, effectively preventing local invasion and recurrence. Therefore, miR-21-5p could be a new therapeutic target, to replace EB irradiation, and control keloid relapse.

    • Li Yan
    • , Lian-Zhao Wang
    • , Ran Xiao
    • , Rui Cao
    • , Bo Pan
    • , Xiao-Yan Lv
    • , Hu Jiao
    • , Qiang Zhuang
    • , Xue-Jian Sun
    •  & Yuan-Bo Liu
  • Article |

    Bone marrow mesenchymal stem cells (BMSC) or BMSC-derived exosome transplantation improves rat ovarian function after chemotherapy-induced ovarian failure. Furthermore, transfer of miR-144-5p using BMSC-derived exosomes decreases granulosa cell (GCs) apoptosis via the PTEN pathway. Thus, a cell-free therapeutic strategy may be possible for ovarian failure.

    • Meiling Yang
    • , Li Lin
    • , Chunli Sha
    • , Taoqiong Li
    • , Dan Zhao
    • , Hong Wei
    • , Qi Chen
    • , Yueqin Liu
    • , Xiaofang Chen
    • , Wenlin Xu
    • , Yuefeng Li
    •  & Xiaolan Zhu
  • Article |

    This study reveals that adhesion molecule ICAM-1 is markedly upregulated in the aorta after angiotensin II infusion. Blockage of soluble ICAM-1 prevents Ang II-induced arterial hypertension and vascular remodeling by reducing macrophage adhesion, suggesting that targeting ICAM-1 may represent a new therapeutic target for hypertension.

    • Ping-Ping Lang
    • , Jie Bai
    • , Yun-Long Zhang
    • , Xiao-Lei Yang
    • , Yun-Long Xia
    • , Qiu-Yue Lin
    •  & Hui-Hua Li
  • Article |

    The role of the prostaglandin E1 receptor EP1 in hypertensive kidney disease remains controversial. EP1 mediates thick ascending limb chloride transport response to prostaglandin E2 and inhibits vasopressin-mediated water transport in the inner medullary collecting duct (IMCD). Though the IMCD transport is unaltered by hypertension, its responsiveness to vasopressin is reduced in diabetes. Moreover, EP1 is protective against glomerular and endothelial injury in hypertensive kidney disease, unlike its harmful role in diabetic kidney disease. This highlights the importance of carefully examining disease state (diabetes vs hypertension) when characterizing underlying disease processes.

    • Rania Nasrallah
    • , Joseph Zimpelmann
    • , Susan J. Robertson
    • , Jamie Ghossein
    • , Jean-Francois Thibodeau
    • , C. R. J. Kennedy
    • , Alex Gutsol
    • , Fengxia Xiao
    • , Dylan Burger
    • , Kevin D. Burns
    •  & Richard L. Hébert
  • Article |

    The authors investigated global analysis coupled shotgun proteomics and in silico metabolic pathway analyses in malignant lymphoma and normal lymphocytes. Trifunctional protein subunit alfa (HADHA) was detected as a lymphoma-specific protein and a prognostic predictor. In vitro, downregulation of HADHA inhibited cell growth and increase susceptibility of cell death stimuli. Therefore, HADHA may be a potential therapeutic target in refractory malignant lymphoma cases.

    • Kouhei Yamamoto
    • , Shinya Abe
    • , Ayaka Honda
    • , Jun Hashimoto
    • , Yuuki Aizawa
    • , Sachiko Ishibashi
    • , Taro Takemura
    • , Nobutaka Hanagata
    • , Masahide Yamamoto
    • , Osamu Miura
    • , Morito Kurata
    •  & Masanobu Kitagawa
  • Article |

    In this study, the authors show that RIP1/RIP3/MLKL-mediated necroptosis is activated in a mouse model of Parkinson’s disease. Blockade of necroptosis through pharmacological intervention by Nec-1 or deletion of RIP3/MLKL gene increased dopamine levels and the number of dopaminergic neurons in mice. Moreover, necroptosis enhanced the expression of pro-inflammatory genes, which may have initiated neuroinflammation and in turn aggravated dopaminergic neuron necroptosis.

    • Qing-Song Lin
    • , Ping Chen
    • , Wei-Xiong Wang
    • , Chen-Chao Lin
    • , Yao Zhou
    • , Liang-Hong Yu
    • , Yuan-Xiang Lin
    • , Yan-Fang Xu
    •  & De-Zhi Kang
  • Technical Report |

    The paper describes a fully automated numerical analysis for an unbiased quantification of non-alcoholic fatty liver disease (NAFLD) histological features in rodent models. The technique offers a quantitative high-throughput method to rapidly detect NAFLD in large preclinical studies and for accurately monitoring disease evolution.

    • Maxime De Rudder
    • , Caroline Bouzin
    • , Maxime Nachit
    • , Heloïse Louvegny
    • , Greetje Vande Velde
    • , Yvon Julé
    •  & Isabelle A. Leclercq
  • Technical Report |

    This study shows a negative regulation of autophagy-related RNA transcripts and the upregulation and downregulation of p62 and LC3-B proteins, respectively, in the central nervous system of scrapie-infected transgenic mice at clinical stage. These findings likely reflect an impairment of the autophagic pathway at the late symptomatic stage of prion infection.

    • Óscar López-Pérez
    • , Janne Markus Toivonen
    • , Alicia Otero
    • , Laura Solanas
    • , Pilar Zaragoza
    • , Juan José Badiola
    • , Rosario Osta
    • , Rosa Bolea
    •  & Inmaculada Martín-Burriel
  • Technical Report
    | Open Access

    The NanoSuit method permits the study of paraffin sections using correlative light and electron microscopy at low and high magnification, with the following features: (i) the integrity of the glass slide is maintained, (ii) 3D microstructures of tissue and pathogens can be visualized, (iii) nuclei and 3,3′-diaminobenzidine-stained areas are distinct because of gold chloride usage, (iv) immunohistochemical staining is quantitative, and (v) contained elements can be analyzed.

    • Hideya Kawasaki
    • , Toshiya Itoh
    • , Yasuharu Takaku
    • , Hiroshi Suzuki
    • , Isao Kosugi
    • , Shiori Meguro
    • , Toshihide Iwashita
    •  & Takahiko Hariyama
  • Article |

    Vitamin D and its analogues demonstrated in this study antifibrotic effects in a murine fibrosis model compared to calcitriol. In this study, the hypocalcemic vitamin D analog paricalcitol was superior in respect to side effects and efficacy, indication that such analogs could be considered for the treatment of liver fibrosis.

    • Florian P. Reiter
    • , Liangtao Ye
    • , Florian Bösch
    • , Ralf Wimmer
    • , Renate Artmann
    • , Andreas Ziesch
    • , Veronika Kanitz
    • , Doris Mayr
    • , Christian J. Steib
    • , Michael Trauner
    • , Ivonne Regel
    • , Alexander L. Gerbes
    • , Julia Mayerle
    • , Simon Hohenester
    • , Enrico N. de Toni
    •  & Gerald Denk
  • Article |

    This study shows that scavenger receptor type I knockout mice (Scarb1-/-) have high adrenocorticotropic hormone (ACTH) levels but are osteopenic. Bone differentiation of Scarb1-/- mesenchymal stem cells at normal ACTH concentrations is reduced. However, 0–10 nM ACTH increases, but 100–1000 nM ACTH reduces wild-type osteoblast differentiation. Therefore, ACTH and the high-density lipoprotein receptor Scarb1 play independent roles in osteoblast differentiation.

    • Irina L. Tourkova
    • , Steven F. Dobrowolski
    • , Cassandra Secunda
    • , Mone Zaidi
    • , Ioanna Papadimitriou-Olivgeri
    • , Dionysios J. Papachristiou
    •  & Harry C. Blair
  • Article |

    Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against endotoxemia-induced kidney injury potentially by means of endothelial hyperpermeability decreasing. Remarkably, TRPM7 inhibition improves survival in endotoxemic animals.

    • Sebastian Gatica
    • , Vicente Villegas
    • , Alejandro Vallejos
    • , Pedro Olivares
    • , Víctor Aballai
    • , Felipe Lagos-Meza
    • , Cesar Echeverria
    • , Claudio Cabello-Verrugio
    • , Diego Varela
    •  & Felipe Simon
  • Article |

    CRISPR/dCas9 blocks TGF-β2-induced mouse double minute 2 (MDM2) expression by targeting its second promoter, without affecting the basal expression. Epithelial to mesenchymal transition is blocked by MDM2 suppression in retinal pigment epithelial cells. In this way, CRIPSR/dCas9 is a promising novel therapy for proliferative vitreoretinopathy without interfering basal gene function.

    • Bing Liu
    • , Jingyuan Song
    • , Haote Han
    • , Zhengping Hu
    • , Na Chen
    • , Jing Cui
    • , Joanne Aiko Matsubara
    • , Jingxiang Zhong
    •  & Hetian Lei
  • Article |

    The Niemann–Pick C1-like intracellular cholesterol transporter gene and a number of genes in the cholesterol synthesis pathway are transcriptionally regulated by SREBP-2. The liganded Ah receptor increases proteolytic turnover of transcriptionally active SREBP2. Thus, Ah receptor ligands are capable of attenuating cholesterol uptake into Caco-2 cells.

    • Gulsum E. Muku
    • , Ann Kusnadi
    • , Guray Kuzu
    • , Rachel Tanos
    • , Iain A. Murray
    • , Krishne Gowda
    • , Shantu Amin
    •  & Gary H. Perdew
  • Article |

    Allergic asthma is one of the most common immune-mediated disorders. The authors investigated the possibility that TPRV4 cation channels facilitate the development of allergic asthma and subsequent pulmonary fibrosis in the lung. Their data suggest that TPRV4 is dispensable in the initiation and development of airway asthma and subsequent fibrosis.

    • Senthilkumar Palaniyandi
    • , Arunraj M. Rajendrakumar
    • , Sivakumar Periasamy
    • , Rishov Goswami
    • , Wenbin Tuo
    • , Xiaoping Zhu
    •  & Shaik O. Rahaman
  • Technical Report |

    In chondrocytes, TGF-β1 increases the expression of hypertrophic genes, suggesting that this treatment could mimic osteoarthritis in vitro. EZH2 and Sik3 inhibition, as well as HIF induction repress the expression of hypertrophy markers in TGF-β stimulated chondrocytes, validating the reliability of this model to predict anti-hypertrophic effects of drugs.

    • Lyess Allas
    • , Quitterie Rochoux
    • , Sylvain Leclercq
    • , Karim Boumédiene
    •  & Catherine Baugé
  • Article |

    This study investigates lipid droplet (LD) trafficking and LD velocity (LDV) in cancer. LD density correlated with prostate tumor grade and high grade tumors had significantly higher LDV when compared to low grade tumors. Acidifying conditions drove up velocities and LDV was normalized with blockade of H+ proton pump, V-ATPase.

    • Francesca Nardi
    • , Philip Fitchev
    • , Kyrsten M. Brooks
    • , Omar E. Franco
    • , Kevin Cheng
    • , Simon W. Hayward
    • , Michael A. Welte
    •  & Susan E. Crawford
  • Article |

    This study was performed to evaluate role of RORα in mouse testicular structure. Lack of RORα expression induces apoptosis, reduces germ cells differentiation, and may cause infertility. RORα is one of the essential proteins regulating testicular structure. RORα-deficient mice may be a suitable model for studying mutation-induced of human infertility.

    • Ramy K. A. Sayed
    • , Doaa M. Mokhtar
    • , Marisol Fernández-Ortiz
    • , Germaine Escames
    •  & Darío Acuña-Castroviejo
  • Technical Report |

    We describe generation of neuroblastoma cell lines using conditional reprogramming (CR)—new cell culture method that allows indefinite propagation of cells in an undifferentiated state. We optimized CR growth conditions for neuroblastoma tissue and grew mouse neuroblastoma cells in vitro. These cells demonstrate a unique phenotype, are positive for neuroblastoma markers, and can be passaged and biobanked for continued studies.

    • Ewa Krawczyk
    • , Sung-Hyeok Hong
    • , Susana Galli
    • , Emily Trinh
    • , Larissa Wietlisbach
    • , Sara F. Misiukiewicz
    • , Jason U. Tilan
    • , You-Shin Chen
    • , Richard Schlegel
    •  & Joanna Kitlinska
  • Article |

    • Sandra Martinez-Morilla
    • , John McGuire
    • , Patricia Gaule
    • , Lauren Moore
    • , Balazs Acs
    • , Delphine Cougot
    • , Allen M. Gown
    • , Hadi Yaziji
    • , Wei-Lien Wang
    • , Richard W. Cartun
    • , Jason L. Hornick
    • , Lynette M. Sholl
    • , Jingxin Qiu
    • , Mari Mino-Kenudson
    • , Eunhee S. Yi
    • , Mary Beth Beasley
    • , Daniel T. Merrick
    • , Abiy B. Ambaye
    • , Zhong J. Zhang
    • , Jill Walker
    •  & David L. Rimm
  • Article |

    Obesity causes complications in the treatment of asthma. This manuscript explores the role of Notch pathway in animal models. The authors found that the inhibition of the Notch pathway by a γ-secretase inhibitor suppresses Th17-associated airway hyperresponsiveness in obese asthmatic mice. This finding may provide a novel insight into asthma treatment in the clinic.

    • Zeyu Zeng
    • , Lei Wang
    • , Weihui Ma
    • , Rongying Zheng
    • , Hong Zhang
    • , Xinxin Zeng
    • , Hui Zhang
    •  & Weixi Zhang
  • Article |

    The severe immunodeficiency of NOD.Cg-PrkdcscidIl2rgtm1Wjl (NSG) mice, a widely used strain for generating patient-derived xenografts from primary tumors, impairs drug metabolism and reduces tolerability towards common cytostatic drugs. Consequently, dose finding and tolerance tests are strongly recommended prior to perform large-scale cancer precision medicine approaches.

    • Claudia Maletzki
    • , Stephanie Bock
    • , Philipp Fruh
    • , Karolis Macius
    • , Anika Witt
    • , Friedrich Prall
    •  & Michael Linnebacher
  • Technical Report |

    The authors provide a side-by-side comparison of morphology and function of primary ductal fragments isolated from mouse pancreas and pancreatic organoid cultures. Using state-of-the-art techniques, they demonstrate that pancreatic organoids can be a suitable and robust model to study pancreatic ductal epithelial ion transport in health and disease.

    • Réka Molnár
    • , Tamara Madácsy
    • , Árpád Varga
    • , Margit Németh
    • , Xénia Katona
    • , Marietta Görög
    • , Brigitta Molnár
    • , Júlia Fanczal
    • , Zoltán Rakonczay Jr.
    • , Péter Hegyi
    • , Petra Pallagi
    •  & József Maléth
  • Article |

    The authors show that Muc5ac−/− mice develop spontaneous gastric antro-pyloric hyperplasia and adenomas. Interestingly, Muc5ac−/− mice have suppression of gastric corpus mucous metaplasia and key proinflammatory cytokines (Tnfα and Il-17a) in a setting of enhanced Helicobacter pylori colonization, thus implying a complex role for Muc5ac in gastric homeostasis.

    • Sureshkumar Muthupalani
    • , Zhongming Ge
    • , Joanna Joy
    • , Yan Feng
    • , Carrie Dobey
    • , Hye-Youn Cho
    • , Robert Langenbach
    • , Timothy C. Wang
    • , Susan J. Hagen
    •  & James G. Fox
  • Article |

    This study shows how telomerase reverse transcriptase (TERT) assists growth differentiation factor 11 (GDF11) to rejuvenate senescent endothelial progenitor cells via the Smad2/3 and eNOS pathways. Therapeutically, it may be possible to exploit TERT mediated-GDF11 signaling to activate senescent stem cells in the myocardial ischemic microenvironment.

    • Lan Zhao
    • , Shaoheng Zhang
    • , Jin Cui
    • , Weiguang Huang
    • , Jiahong Wang
    • , Feng Su
    • , Nannan Chen
    •  & Qunlin Gong