George F Murphy

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Advancing the understanding of human and experimental disease

Latest Research

  • Article |

    In this study, the authors show that arctigenin (AG) inhibits the inflammatory myeloid phenotype and alleviates heart damage after myocardial infarction. Mechanically, the transcription factor NFAT5 is involved in the cardioprotective effect of AG via the JAK/STAT and NF-κB signaling pathways.

    • Shi-Hao Ni
    • , Shu-Ning Sun
    • , Zheng Zhou
    • , Yue Li
    • , Yu-Sheng Huang
    • , Huan Li
    • , Jia-Jia Wang
    • , Wei Xiao
    • , Shao-Xiang Xian
    • , Zhong-Qi Yang
    • , Ling-Jun Wang
    •  & Lu Lu
  • Article |

    The authors examined the mechanisms underlying the lineage switch from prostate adenocarcinoma (AdPC) to lethal neuroendocrine prostate cancer (NEPC). They identified SRY-related HMG-box gene 2 (SOX2) as a potential repressor that causes decreased expression of AdPC-specific genes in NEPC. The repressor role of SOX2 is attributed to the marked global hypomethylation of histone H3, which is driven by the activation of lysine-specific demethylase 1 (LSD1).

    • Haiying Li
    • , Lili Wang
    • , Zhang Li
    • , Xu Geng
    • , Ming Li
    • , Qi Tang
    • , Chunxiao Wu
    •  & Zhiming Lu
  • Technical Report |

    The hedgehog pathway is pivotal in basal cell carcinoma and medulloblastoma development. Gorlin syndrome-derived, induced pluripotent stem cells (iPSCs) carrying a heterozygous mutation in PTCH1, a hedgehog target gene, exhibited high GLI1 expression and enhanced sensitivity to a hedgehog pathway inhibitor after neural differentiation. These iPSCs can serve as a model for hedgehog pathway-related tumors.

    • Hajime Ikehara
    • , Katsunori Fujii
    • , Toshiyuki Miyashita
    • , Yu Ikemoto
    • , Marina Nagamine
    • , Naoki Shimojo
    •  & Akihiro Umezawa
  • Article |

    In the glioma microenvironment, tumor-associated macrophages secrete large amounts of chemokine (C-C motif) ligand 8 CCL8, which contributes to pseudopodia formation of glioblastoma cells and promotes progression of glioma. CCL8 induces invasion and stem-like traits of glioblastoma cells via CCR1/ CCR5-mediated ERK1/2 activation.

    • Xiang Zhang
    • , Lu Chen
    • , Wei-qi Dang
    • , Mian-fu Cao
    • , Jing-fang Xiao
    • , Sheng-qing Lv
    • , Wen-jie Jiang
    • , Xiao-hong Yao
    • , Hui-min Lu
    • , Jing-ya Miao
    • , Yan Wang
    • , Shi-cang Yu
    • , Yi-fang Ping
    • , Xin-dong Liu
    • , You-hong Cui
    • , Xia Zhang
    •  & Xiu-wu Bian
  • Article |

    Vascular endothelial growth factor increases the profibrotic activity of atrial fibroblasts by activating the currents through transient receptor potential channels and intermediate-conductance calcium-activated K+ (KCa3.1) channels and by enhancing Ca2+ entry-induced phosphorylated Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling. These findings suggest a novel strategy targeting atrial myopathy and arrhythmofibrosis.

    • Cheng-Chih Chung
    • , Yung-Kuo Lin
    • , Yao-Chang Chen
    • , Yu-Hsun Kao
    • , Ting-I Lee
    •  & Yi-Jen Chen
  • Article |

    The authors evaluated the efficiency of different maternal diet interventions on reducing the risk for offspring nonalcoholic fatty liver disease due to maternal overnutrition. They found that that different maternal diet interventions prime the lipid metabolism differently via changes in lipogenesis and β-oxidation through insulin/AKT signaling and 5′ AMP-activated protein kinase signaling.

    • Yi Zhou
    • , Hui Peng
    • , Huiting Xu
    • , Jiangyuan Li
    • , Mikhail Golovko
    • , Henghui Cheng
    • , Ernest C. Lynch
    • , Lin Liu
    • , Naomi McCauley
    • , Lindsey Kennedy
    • , Gianfranco Alpini
    • , Ke K. Zhang
    •  & Linglin Xie

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United States & Canadian Academy of Pathology 108th Annual Meeting Abstracts: Unlocking Your Ingenuity

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