George F Murphy

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Advancing the understanding of human and experimental disease

Latest Research

  • Article |

    The expression of the stimulator of interferon genes (STING) in liver tissues is associated with the progression of human nonalcoholic fatty liver disease. Specifically, STING-expressing macrophages, in particular, monocyte-derived macrophages, are positively correlated with the degree of liver inflammation and/or fibrosis progression, which appeared to be mediated by the activation of the STING-TBK1 signaling pathway in macrophage.

    • Xiaoxiao Wang
    • , Huiying Rao
    • , Jingmin Zhao
    • , Aileen Wee
    • , Xiaohe Li
    • , Ran Fei
    • , Rui Huang
    • , Chaodong Wu
    • , Feng Liu
    •  & Lai Wei
  • Article |

    In this paper, the authors found that conditional ablation of Shp2 in mouse K14-positive corneal epithelium (Shp2K14ce-cko) impairs corneal innervation and results in corneal epithelial thinning, which resembles neurotrophic keratopathy. Furthermore, the data indicate that Shp2 signaling plays a pivotal role in corneal epithelial homeostasis.

    • Yuka Okada
    • , Yujin Zhang
    • , Lingling Zhang
    • , Lung-Kun Yeh
    • , Yen-Chiao Wang
    • , Shizuya Saika
    •  & Chia-Yang Liu
  • Review Article |

    Transient receptor ion channels have emerged as critical channels/receptors in numerous physiological and pathological conditions. In this paper the authors discuss our current understanding of the role of macrophage transient receptor potential channel subfamily V member 4 (TRPV4) in various inflammatory conditions.

    • Bidisha Dutta
    • , Rakesh K. Arya
    • , Rishov Goswami
    • , Mazen O. Alharbi
    • , Shweta Sharma
    •  & Shaik O. Rahaman
  • Article |

    Polydatin (PD) protects against LPS-induced vascular leakage in multiple organs and this effect is dependent on SIRT3 activation. PD enhances SIRT3-mediated deacetylation of SOD2 and CypD, thus suppressing mitochondrial dysfunction and subsequent endothelial barrier dysfunction. In addition, RAGE is involved in LPS-regulated SIRT3 signaling.

    • Jie Wu
    • , Zhiya Deng
    • , Maomao Sun
    • , Weijin Zhang
    • , Yang Yang
    • , Zhenhua Zeng
    • , Jianhua Wu
    • , Qin Zhang
    • , Yanan Liu
    • , Zhenfeng Chen
    • , Xiaohua Guo
    • , Ke-seng Zhao
    • , Qiaobing Huang
    •  & Zhongqing Chen
  • Article |

    The authors reveal that TRPV4, a thermosensitive ion channel, is constitutively active in the brain. They found that local brain temperature is increased at epileptogenic foci, and that hyperthermia lead TRPV4 over-activation and hyper-neuronal activities. Notably, brain cooling treatment drastically suppresses epileptic discharges dependent on the inactivation of TRPV4.

    • Koji Shibasaki
    • , Katsuya Yamada
    • , Hideki Miwa
    • , Yuchio Yanagawa
    • , Michiyasu Suzuki
    • , Makoto Tominaga
    •  & Yasuki Ishizaki

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