Commentary
Kidney International (2008) 74, 259–261. doi:10.1038/ki.2008.260
Glomerular filtration: the charge debate charges ahead
Jeffrey H Miner1
1Renal Division, Department of Internal Medicine, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA
Correspondence: Jeffrey H. Miner, Renal Division 8126, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. E-mail: minerj@wustl.edu
Abstract
The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.
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