Commentary
Kidney International (2008) 74, 261–262. doi:10.1038/ki.2008.221
When less is more: apoptosis during acute kidney injury
Istvan Arany1
1Department of Pediatrics, Division of Pediatric Nephrology, University of Mississippi Medical Center, Research Wing, Jackson, Mississippi, USA
Correspondence: Istvan Arany, Department of Pediatrics, Division of Pediatric Nephrology, University of Mississippi Medical Center, Research Wing, Room R129B, 2500 North State Street, Jackson, Mississippi 39216-4505, USA. E-mail: iarany@ped.umsmed.edu
Abstract
The paper by Ma and Devarajan suggests that the subtle apoptotic events that occur in the distal nephron after acute kidney injury might have a greater than expected impact on the adjacent proximal tubules and kidney function. Understanding these events might facilitate development of therapeutic means to ameliorate acute kidney injury.
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