1. ¹Providence Medical Research Center at Sacred Heart Medical Center, Spokane, Washington, USA
2. ²University of Washington School of Medicine, Spokane, Washington, USA

Correspondence: KR Tuttle, Providence Medical Research Center, 122 W. 7th Avenue, Suite 230, Spokane, Washington 99224, USA. E-mail: ktuttle@this.org

Abstract

Increased urinary excretion of albumin or total protein has become firmly established as a risk predictor for progression of chronic kidney disease. Observational analyses have raised a strong hypothesis that albuminuria reduction should be a clinical treatment target. Bakris et al. report further exploration of albuminuria-lowering capabilities of intensified renin–angiotensin system inhibition in a randomized clinical trial that included patients at high cardiovascular risk, most of whom appeared to have diabetic kidney disease.