1. ¹Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
2. ²Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA

Correspondence: ED Poggio, Renal Function Laboratory, Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk A51, Cleveland, Ohio 44195, USA. E-mail: poggioe@ccf.org

Abstract

The Modification of Diet in Renal Disease (MDRD) equation has been used to screen for and diagnose chronic kidney disease (CKD). A fixed estimated glomerular filtration rate cutoff point has been advocated by the National Kidney Foundation to diagnose CKD. However, data derived from healthy individuals challenge this approach and suggest that age- and gender-specific reference values may be more useful in the screening setting.