Commentary
Kidney International (2007) 71, 1199–1202; doi:10.1038/sj.ki.5002286
Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity
S P Bagby1
1Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA
Correspondence: SP Bagby, Division of Nephrology and Hypertension, Oregon Health & Science University, 3314 SW U.S. Veterans Hospital Road (PP262), Portland, Oregon 97239-2940, USA. E-mail: bagbys@ohsu.edu
Abstract
Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.
