TABLE 2
FROM:
Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
K J Schjoedt, K Rossing, T R Juhl, F Boomsma, L Tarnow, P Rossing and H-H Parving
BACK TO ARTICLETable 2. Effects of adding spironolactone 25 mg o.d. to ongoing recommended antihypertensive treatment in 20 patients with diabetic nephropathy and nephrotic range albuminuria
| Conventional antihypertensive treatment | Mean difference (95% CI) | P-value | ||
|---|---|---|---|---|
| +Placebo | +Spironolactone 25 mg | |||
| Albuminuria (mg/24 h)a | 3718 (2910–4749) | 2510 (1831–3441) | -32% (-42 to -21) | <0.001 |
| Systolic blood pressure (mm Hg) | ||||
| Office | 146 (4) | 142 (4) | -4 (-11 to 4) | 0.32 |
| 24-hb | 143 (3) | 137 (3) | -6 (-10 to -2) | 0.004 |
| Day (7–23)b | 147 (3) | 140 (4) | -7 (-12 to -3) | 0.002 |
| Night (23–7)c | 135 (3) | 133 (4) | -2 (-7 to 2) | 0.32 |
| Diastolic blood pressure (mm Hg) | ||||
| Office | 76 (2) | 73 (2) | -3 (-6 to 0.4) | 0.08 |
| 24-hb | 81 (2) | 77 (2) | -4 (-6 to -2) | 0.001 |
| Day (7–23)b | 84 (2) | 80 (2) | -5 (-7 to -3) | <0.001 |
| Night (23–7)c | 74 (2) | 73 (2) | -1 (-4 to 2) | 0.44 |
| GFR (ml/min/1.73 m2) | 64 (2) | 62 (2) | -3 (-6 to 1) | 0.13 |
Fractional albumin clearance (
alb) (  10-6)a
| 1.79 (1.25–2.56) | 1.24 (0.82 to1.87) | -31% (-40 to -20) | <0.001 |
| Urinary sodium excretion (mmol/24 h) | 239 (36) | 210 (19) | -29 (-84 to 26) | 0.28 |
| Urinary K/Na ratio | 0.43 (0.05) | 0.43 (0.04) | 0.01 (-0.06 to 0.07) | 0.78 |
| Bodyweight (kg) | 93.8 (5.7) | 92.6 (5.6) | 1.1 (-0.1 to 2.4) | 0.07 |
| Plasma renin activity (ng AI/ml/h)a | 8.9 (5.8–13.5) | 16.1 (9.2–28.1) | 81% (25–162) | 0.003 |
| Plasma aldosterone (pg/ml)a | 38 (25–56) | 68 (50–93) | 80% (23–163) | 0.004 |
Plasma creatinine ( mol/l) | 141 (15) | 149 (15) | 8 (-4 to 20) | 0.17 |
| Plasma potassium (mmol/l) | 4.1 (0.1) | 4.3 (0.1) | 0.2 (-0.004 to 0.5) | 0.054 |
| Plasma sodium (mmol/l) | 139 (1) | 138 (1) | -1 (-3 to 1) | 0.28 |
| Hemoglobin (mmol/l) | 7.6 (0.2) | 7.3 (0.2) | -0.2 (-0.5 to 0.01) | 0.057 |
| Hemoglobin A1c (%) | 8.2 (0.3) | 8.4 (0.3) | 0.2 (-0.1 to 0.5) | 0.20 |
| Plasma cholesterol (mmol/l) | 4.7 (0.3) | 4.6 (0.2) | -0.1 (-0.4 to 0.3) | 0.74 |
| Plasma LDL cholesterol (mmol/l) | 2.3 (0.2) | 2.3 (0.2) | 0.0 (-0.3 to 0.3) | 0.88 |
| Plasma HDL cholesterol (mmol/l) | 1.5 (0.2) | 1.5 (0.1) | -0.07 (-0.2 to 0.04) | 0.20 |
GFR, glomerular filtration rate; LDL, low-density lipoprotein; HDL, high-density lipoprotein; CI, confidence interval.
Data are expressed as mean (s.e.).
a Geometric mean (95% CI).
b n=18 because of insufficient measurements.
c n=17 because of insufficient measurements.
