Cell Biology – Immunology – Pathology

Kidney International (2005) 67, 1391–1396; doi:10.1111/j.1523-1755.2005.00216.x

Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma

KEIICHI TOZAWA, TAKASHI OKAMOTO, NORIYASU KAWAI, YOSHIHIRO HASHIMOTO, YUTARO HAYASHI and KENJIRO KOHRI

Department of Nephro-urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan; and Department of Molecular Genetics, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan

Received 17 September 2004; Revised 2 November 2004; Accepted 11 November 2004.

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Abstract

Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma.

Background

 

Interaction between tumor cells and endothelium plays a major role in cancer invasion and metastasis. Among various cell adhesion molecules, the cognate interaction between sialyl Lewis antigen expressed in the tumor cell surface and E-selectin expressed on endothelial cells is considered to be crucial for the tumor cell adhesion to the endothelium.

Methods

 

The sialyl Lewis X (sLX) expression in 45 specimens from renal cell carcinoma patients was examined using immunohistochemistry.

Results

 

In this study, we demonstrate that the immunoreactivity for sLX in renal cell carcinoma specimens not only correlates with conventional histopathologic parameters but also serves as a useful indicator for the prognosis of renal cell carcinoma.

Conclusion

 

Since beneficial effect of cimetidine has been reported and ascribed to its inhibitory action on the expression of E-selectin, a ligand molecule of sialyl Lewis antigen, cimetidine may also show inhibitory effect on the tumor recurrence and metastasis of renal cell carcinoma with high level of sLX expression.

Keywords:

sialyl Lewis antigen, renal cell carcinoma, cimetidine

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