TABLE 2
FROM:
Risk factors for renal replacement therapy in the Early Treatment Diabetic Retinopathy Study (ETDRS), Early Treatment Diabetic Retinopathy Study Report No. 26
MICHAEL CUSICK, EMILY Y CHEW, BYRON HOOGWERF, ELVIRA AGRÓN, LIELING WU, ANNA LINDLEY and FREDERICK L FERRIS III T
BACK TO ARTICLETable 2. Risk factors for renal replacement therapy (RRT): Results of the final hazards ratio (HR) modelsa
| Characteristic | Type 1 diabetesb HR (99% CI) | Type 2 diabetesc HR (99% CI) |
|---|---|---|
| Age per 1 year decrement | 1.01 (0.98–1.04) | 1.04 (1.01–1.07) |
| Body mass index kg/m2 | ||
| Per 1 kg/m2 decrement | 1.14 (1.05–1.23) | |
| <25 | 1.00 (—) | |
| 25 to <30 | 0.66 (0.38–1.16) | |
 30 | 0.24 (0.05–1.14) | |
| Duration of diabetes per year | 0.94 (0.90–0.99) | |
| Systolic blood pressure mm Hg | ||
| Per 10 mm Hg increment | 1.20 (1.04–1.39) | |
| <130 | 1.00 (—) | |
| 130 | 1.33 (0.77–2.31) | |
| Hemoglobin A1c% | ||
| Per 1% increment | 1.21 (1.07–1.38) | 1.09 (0.99–1.21) |
| <7.5% | 1.00 (—) | 1.00 (—) |
| 7.5% to <9.0% | 3.87 (0.27–55.36) | 1.34 (0.60–3.04) |
| 9.0% to <10.5% | 3.79 (0.27–52.53) | 1.39 (0.65–2.99) |
| 10.5% to <12.0% | 5.31 (0.38–74.20) | 1.72 (0.76–3.89) |
| 12.0% | 7.43 (0.53–103.84) | 1.95 (0.84–4.52) |
| Total cholesterol mmol/L | ||
| Per 0.259 mmol/L increment | 1.08 (1.03–1.12) | 1.04 (1.00–1.08) |
| <5.180 | 1.00 (—) | 1.00 (—) |
| 5.180 to <6.216 | 1.03 (0.53–2.00) | 0.73 (0.39–1.37) |
| 6.216 | 2.33 (1.25–4.34) | 1.12 (0.62–1.97) |
| Triglycerides mmol/L | ||
| Per 0.113 mmol/L increment | 1.01 (1.00–1.03) | |
| <1.695 | 1.00 (—) | |
| 1.695 to <2.260 | 1.06 (0.55–2.02) | |
| 2.260 | 1.59 (0.93–2.69) | |
Serum creatinine  mol/L
| ||
Per unit increment of log 1  mol/L | 8.74 (3.17–24.06) | 17.49 (8.10–37.77) |
| <132.6 | 1.00 (—) | 1.00 (—) |
| 132.6 to 176.8 | 5.17 (2.28–11.72) | 6.13 (3.49–10.79) |
| 176.8 | 10.86 (3.47–34.01) | 10.74 (4.36–26.47) |
| Serum albumin g/L | ||
| Per 10 g/L decrement | 2.54 (1.51–4.27) | 2.85 (1.77–4.57) |
| 35.0 | 1.00 (—) | 1.00 (—) |
| 30.0 to <35.0 | 1.98 (1.01–3.86) | 2.21 (1.23–3.99) |
| <30.0 | 3.18 (1.55–6.55) | 2.74 (1.42–5.28) |
| Proteinuria present | 1.47 (0.85–2.57) | 2.43 (1.52–3.89) |
| Hematocrit | ||
| Male >50%, female >44% | 1.00 (—) | 1.00 (—) |
| Male 45% to <50%, female 40% to <44% | 1.16 (0.53–2.53) | 1.36 (0.61–3.04) |
| Male 40% to <45%, female 34% to <40% | 1.62 (0.75–3.46) | 1.86 (0.85–4.08) |
| Male <40%, female <34% | 4.62 (1.63–13.09) | 4.12 (1.62–10.39) |
| Developed proliferative diabetic retinopathy | 2.65 (1.40–5.02) | |
a RRT is defined as the need for renal dialysis or transplant. Hazard ratios (HRs) with P value 
0.01 are shown in bold. HRs not significant at P 0.01 and categories presented for comparison. Missing HRs did not make the final model for that type diabetes.
b In addition to those variables represented in the column, the final Cox regression model for type 1 diabetes is also adjusted for race, gender, and alcohol consumption.
c In addition to those variables represented in the column, the final Cox regression model for type 2 diabetes is also adjusted for race, gender, diabetic retinopathy, and neuropathy.
