TABLE 4

FROM:

Impairment of phenylalanine conversion to tyrosine inend-stage renal disease causing tyrosine deficiency

YVES BOIRIE, ROBERT ALBRIGHT, MAUREEN BIGELOW and K SREEKUMARAN NAIR

Table 4. Plasma amino acid concentrations during saline and during amino acid infusion

	Saline		Amino acid
	Controls	ESRD	Controls	ESRD
Glutamic acid	43 11	51 10	44 11	55 16
Serinle	69 16	49 15	147 43a	112 21
Glutamine	465 73	427 137	465 81	406 103
Histidine	56 8	51 15	78 9a	72 17
Glycine	209 65	356 193	674 162a	825 235
Threonine	87 18	80 33	180 53a	174 55
Alanine	237 65	189 52	497 87a	418 79
Arginine	103 30	92 18	252 59a	222 38
Tyrosine	58 11	34 12b	52 13	30 9b
Valine	183 46	104 26b	417 105a	327 54
Methionine	30 8	24 10	95 12a	75 7
Phenylalanine	63 15	53 12	131 29a	126 10
Isoleucine	54 10	41 12	177 31a	162 15
Leucine	116 22	70 21b	289 44a	236 21
Lysine	189 26	133 34b	370 36a	282 49

 ESRD is end-stage renal disease. Mean SD.

^a Indicates that both controls and ESRD increased (P < 0.05) during amino acid infusion in comparision with saline.

^b  P < 0.05 ESRD vs. control subjects.