TABLE 1

First author	Publication year	Country of origin	Number of patients	Blinding	Diagnostic study	NAC regimen	Cointervention
Oldemeyer24	2003	U.S.A.	96	Double	Coronary angiography	1500 mg po bid 48 hours	0.45% saline 1 mL/kg/hr 12 hours pre and 12 hours post
Loutrianakisa	2003	U.S.A.	47	No	Coronary or peripheral angiography	600 mg bid 48 hours	0.45% saline 1 mL/kg/hr (outpatients 4 h, inpatients 12 h)
Baker21	2003	U.K.	80	No	Coronary angiography/angioplasty	IV NAC 150 mg/kg over 30 minutes pre followed by 50 mg/kg over 4 hours	0.9% saline 1 mL/kg/hr for 12 hours pre and 12 hours post (placebo)a
Le Feuvre	2003	France	120	No	Coronary angiography	600 mg bid 4 doses	0.9% saline 1 mL/kg/hr for 12 hours pre and 12 hours post
Kay7	2003	China	200	Double	Coronary angiography/angioplasty	600 mg po bid 48 hours	0.9% saline 1 mL/kg/hr 12 hours pre and 6 hours post
Durham8	2002	U.S.A.	79	NS	Coronary angiography/angioplasty	1200 mg po 1 hr pre, 3 hrs post	0.45% saline 1 mL/kg/hr 12 hours pre and 12 hours post
Briguori17	2002	Italy	183	No	Coronary or peripheral angiography/angioplasty	600 mg po bid, 48 hours	0.45% saline 1 mL/kg/hr 12 hours pre and 12 hours post
Diaz-Sandoval18	2002	U.S.A.	54	Double	Coronary angiography/angioplasty	600 mg po bid, 48 hours	0.45% saline 1 mL/kg/hr 2–12 hours pre and 12 hours post
Shyu19	2002	Taiwan	121	Single	Coronary angiography/angioplasty	400 mg po bid, 48 hours	0.45% saline 1 mL/kg/hr 12 hours pre and 12 hours post
Vallero20	2002	Italy	100	No	Coronary angiography	600 mg po bid, 48 hours	0.45% saline 1 mL/kg/hr 2 hours pre for total of 24 hours
Allaqaband9 a	2002	U.S.A.	85	No	Coronary or peripheral angiography	600 mg po bid, 48 hours	0.45% saline 12 hours pre and 12 hours post
Kahlon	2002	U.S.A.	51	Double	Coronary angiography	600 mg po bid 48 hours	0.9% saline 1 mL/kg/hr 12 hours pre and 12 hours post‡
Ochoa23	2002	U.S.A.	80	Double	Coronary angiography/angioplasty	1000 mg po 1 hour pre and 4 hours post	0.45% saline, minimum volume 1000 mL
Azmus22	2002	Brazil	397	Double	Coronary angiography	600 mg po bid 2 doses pre and 3 doses post cath	2L 0.9% saline (1 L pre-, 1 L post-)
Tepel6	2000	Germany	83	No	Computed tomography	600 mg po bid, 48 hours	0.45% saline 12 hours pre and 12 hours post

Definition of CIN	Volume of contrast mL	Age	Female %	Diabetic %	Baseline serum creatinine mg/dL	Non-ionic, low-molecular-weight contrast
25% increase in SCr or 0.5 mg/dL increase in serum SCr at 48 hours	130.6	76	45	45	1.65	Yes
25% increase in SCr	147	67	31.9	36	1.94	Yes
25% increase in SCr at 48 hours	230.2	69	12.5	42.5	1.81	Yes
25% increase in SCr at 48 hours	176.5	67	19	30	1.91	Yes
>25% increase in SCr within 48 hours after cath	125.1 (median)	69	38.5	37.5	1.25	Yes
0.5 mg/dL increase in SCr at 48 hours post cath	82.9	71	34	48	2.25	Yes
25% increase in SCr at 48 hours or need for dialysis	197	64	13.4	36	1.53	Yes
>25% increase in SCr or 0.5 mg/dL increase in SCr at 48 hours post cath	184	73	20.2	50	1.61	Yes
0.5 mg/dL increase in serum SCr at 48 hours post cath	117	70	32	63.5	2.8	Yes
0.5 mg/dL or 33% increase in SCr at 48 hours post contrast	203.9	62	24	23	0.91	Yes
0.5 mg/dL increase in SCr at 48 hours	121.5	71	39	48	2.12	Yes
0.5 mg/dL increase in SCr at 96 hours post cath	124	69	36	63	2.06	Yes
>25% increase in SCr or >0.5mg/dL at 48 hours post cath	141.9	71	56	55	1.93	Yes
25% increase in SCr or absolute increase in SCr 0.5 mg/dL at 24 to 48 hours post cath	125.5	66	41	50	1.29	No
0.5 mg/dL increase in SCr at 48 hours post cath	75	66	43	33	2.4	Yes

 NAC recipients received 500 mL of intravenous saline during the procedure, and 500 mL over 4-hour post-procedure. Some participants received only a 70 mL/kg bolus of intravenous saline.

^a These trials had three experimental arms: NAC, fenoldopam, and control. Table considers only the NAC and control arms.