Kidney International

FIGURE 2

FROM:

Polycystic kidney syndrome in New Zealand White rabbits resembling human polycystic kidney disease

KIRK J MAURER, ROBERT P MARINI, JAMES G FOX and ARLIN B ROGERS

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Figure 2.

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Histopathology of polycystic kidney syndrome (PKS). Normal rabbit kidney (A) versus segmentally variable lesions in kidney with PKS (B). Three polycystic kidney syndrome–defining criteria: (1) cystic or microcystic lesions affecting tubules, glomeruli, or both (C); (2) loose mesenchymal expansion of interstitium (D); and (3) irregular thickening (arrow), thinning, and/or splitting of basement membranes (E). Mineralization with artifactual fissure (arrow) in tunica media of muscular artery resembling Mönckeberg's medial calcific sclerosis (F). Hepatic lesions associated with PKS including mild chronic cholangitis and pericholangitis (G) and cholangiodysplasia and fibrosis (H). H&E, hematoxylin & eosin; bar = 500 mu (A, B), 100 mu (C, H), 250 mu (D), or 50 mu (E, F, G).

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