TABLE 1

FROM:

Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats

Kyoko Katsumata, Kenichiro Kusano, Michinori Hirata, Kunihiko Tsunemi, Nobuo Nagano, Steven K Burke and Naoshi Fukushima

Table 1. Effect of sevelamer on calcification of soft tissues

	Normal (N = 5)					Adenine control (N = 10)					Adenine-1% sevelamer (N = 6)					Adenine-2% sevelamer (N=10)
	-		+	++	+++	-		+	++	+++	-		+	++	+++	-		+	++	+++
Aorta media	5	0	0	0	0	1	1	0	1	7	5	0	0	1	0	9	0	0	0	1
						P = 0.003a					P = 0.006b					P = 0.001b
Kidney	5	0	0	0	0	3	1	3	1	2	4	1	1	0	0	7	2	1	0	0
						P = 0.023a					P = 0.134b					P = 0.045b
Stomach muscular layer	5	0	0	0	0	0	0	3	5	2	1	3	2	0	0	9	0	0	1	0
						P = 0.002a					P = 0.051b					P < 0.001b
Stomach mucosa	5	0	0	0	0	1	1	7	1	0	1	3	2	0	0	9	0	0	1	0
						P = 0.003a					P = 0.445b					P = 0.002b

 -, No change; , very slight; +, slight; ++, moderate; +++, severe.

^a vs. normal (Wilcoxon rank-sum test)

^b vs. adenine control (Steel test)