Kidney International

FIGURE 10

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Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats

Kyoko Katsumata, Kenichiro Kusano, Michinori Hirata, Kunihiko Tsunemi, Nobuo Nagano, Steven K Burke and Naoshi Fukushima

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Figure 10.

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Sevelamer prevents the progression of ROD in adenine-induced renal failure rats. (A to D) show typical hematoxylin-eosin stains of femur of normal controls (A), adenine controls (B and C), or 2% sevelamer-treated rats (D) at day 35 after administration. Increases in osteoid (*), porosity in the cortical bone, fibrosa (Fb), the activation of osteoblasts (arrow) and osteoclasts (arrow head) were observed in adenine-induced renal failure rats (C). Sevelamer prevented these pathologic findings of renal osteodystrophy (ROD). Magnification of (A, B, D), times2; magnification of (C), times10.

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