FIGURE 4
FROM:
Depolymerized holothurian glycosaminoglycan (DHG), a novel alternative anticoagulant for hemodialysis, is safe and effective in a dog renal failure model
Kazuhisa Minamiguchi, Keiko T Kitazato, Hideki Nagase, Eiji Sasaki, Katsuo Ohwada and Kenji Kitazato
BACK TO ARTICLEFigure 4.
Hemorrhagic effects of depolymerized holothurian glycosaminoglycan (DHG), unfractionated heparin (UFH), and low-molecular-weight heparin (LMWH). The template device was applied to the ear surface with care taken to avoid large veins, and blood from the wound was collected. Blood loss is expressed as hemoglobin content (see Methods section). Template bleeding was measured before surgery performed to induce renal failure (stage 1), prehemodialysis (HD-pre), and at 3 hours after the start of hemodialysis (HD-3 hr). Abbreviations are: D, DHG, 5 mg/kg bolus + 2.5 mg/kg/hour drip infusion; U, UFH, 1 mg/kg bolus + 0.5 mg/kg/hour drip infusion; L, LMWH, 3 mg/kg bolus + 1.5 mg/kg/hour drip infusion. Results indicate the mean 
SD (N = 5). *P < 0.05 vs. prehemodialysis values by paired t test.
