FIGURE 9
FROM:
Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death
Kazuhiko Tsuruya, Toshiharu Ninomiya, Masanori Tokumoto, Makoto Hirakawa, Kohsuke Masutani, Masatomo Taniguchi, Kyoichi Fukuda, Hidetoshi Kanai, Kenji Kishihara, Hideki Hirakata and Mitsuo Iida
BACK TO ARTICLEFigure 9.
Cell viability of murine PTCs determined by WST-1 assay. Symbols are: C57BL/6 mice (
), C57BL/6-lpr/lpr mice (
), and TNFR1
-/- mice (
). Cell viability was determined by WST-1 assay as described in the Methods section. Results are expressed as the percentage of the value obtained without cisplatin. The experiments were performed in triplicate, and the mean values (
SEM) are plotted. A dose-dependent killing of PTCs by the 72-hour exposure to cisplatin is shown. The PTCs of C57BL/6-lpr/lpr mice and TNFR1
-/- mice were significantly more resistant to cisplatin stimulation than those of C57BL/6 mice. **P < 0.01 compared to C57BL/6 mice.
