Kidney International

FIGURE 8

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Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death

Kazuhiko Tsuruya, Toshiharu Ninomiya, Masanori Tokumoto, Makoto Hirakawa, Kohsuke Masutani, Masatomo Taniguchi, Kyoichi Fukuda, Hidetoshi Kanai, Kenji Kishihara, Hideki Hirakata and Mitsuo Iida

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Figure 8.

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Number of apoptotic cells in the murine kidneys 3 days after cisplatin injection determined by TUNEL assay. Representative kidney sections are from C57BL/6 mice (A), C57BL/6-lpr/lpr mice (B), and TNFR1 -/- mice (C) (magnification, times200). (D) The numbers of TUNEL-positive cells in the kidney sections at low-power field were counted. Values represent means (plusminus SEM) of kidney sections from at least five mice (*P < 0.05; **P < 0.01 compared to C57BL/6 mice).

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