Kidney International

FIGURE 1

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Nitric oxide increases adrenomedullin receptor function in rat mesangial cells

Jörg Dötsch, Ellen Schoof, Harald O Schöcklmann, Bernhard Brüne, Ina Knerr, Reinald Repp and Wolfgang Rascher

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Figure 1.

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Adrenomedullin (ADM) radioligand binding assay showing the increase in ADM binding after 24 hours of incubation with 100 mumol/L of each of the two NO donors GSNO and SNAP (P < 0.001 for both NO donors). Symbols are: (circle) control; () GSNO 100 mumol/L; () SNAP 100 mumol/L. Values are presented as the mean plusminus SEM. The maximal binding of the GSNO pretreated cells was normalized to 100%. The results are based on 6 experiments.

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