Kidney International

FIGURE 2

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Response of mesangial cells to low-density lipoprotein and angiotensin II in diabetic (OLETF) rats

Mitsuru Okada, Tsukasa Takemura, Hidehiko Yanagida and Kazuo Yoshioka

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Figure 2.

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Immunofluorescent staining for type III collagen in OLETF and LETO rat glomeruli. The accumulation of type III collagen was evident in the mesangial areas in 45-week-old OLETF rats (B), but much less evident in 15-week-old OLETF (A) and 45-week-old LETO (C) rats. A negative control section of a 45-week-old OLETF rat, stained with non-immune rabbit serum, followed by FITC-labeled secondary antibodies, is shown in (D). Original magnifications were times400.

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