Kidney International

FIGURE 10

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Response of mesangial cells to low-density lipoprotein and angiotensin II in diabetic (OLETF) rats

Mitsuru Okada, Tsukasa Takemura, Hidehiko Yanagida and Kazuo Yoshioka

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Figure 10.

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Northern blot analysis for type I and III collagen mRNA (A) and TGF-beta mRNA (B) in Ang II-stimulated MCs from OLETF and LETO rats. (A) Incubation with Ang II (Ang II+) resulted in up-regulation of type I and III collagen mRNAs in o-OLETF MCs, but not in y-OLETF and LETO MCs. (B) After incubation of MCs with Ang II, TGF-beta mRNA expression was stronger in o-OLETF MCs than in y-OLETF or o-LETO MCs. In untreated MC cultures in FCS, TGF-beta mRNA expression was minimal in OLETF and LETO rats (as shown in Figure 8b).

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