Kidney International

FIGURE 1

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Response of mesangial cells to low-density lipoprotein and angiotensin II in diabetic (OLETF) rats

Mitsuru Okada, Tsukasa Takemura, Hidehiko Yanagida and Kazuo Yoshioka

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Figure 1.

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Microscopic findings (A–E) and low-density lipoprotein (LDL) deposition (F–J) in glomeruli of Otsuka Long-Evans Tokushima Fatty (OLETF) and Long-Evans Tokushima Otsuka (LETO) rats. Glomerular changes were minimal in 15-week-old OLETF rats (A). An increase of mesangial cells was seen in 25-week-old OLETF rats (B). ECM accumulation was evident in 45-week-old OLETF rats (C) and "nodular lesions" were present in 65-week-old OLETF rats (D), while only minor glomerular changes were seen in 65-week-old LETO rats (E). Glomerular LDL deposition was seen in 15- (F) and 25-week-old (G) OLETF rats. LDL deposition was intense in glomeruli of 45- (H) and 65-week-old (I) OLETF rats, whereas it was weak in glomeruli of 65-week-old LETO rats (J). Original magnifications were times400.

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