Kidney International

FIGURE 1

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Glomerular protein sieving and implications for renal failure in Fanconi syndrome

Anthony GW Norden, Marta Lapsley, Philip J Lee, Charles D Pusey, Steven J Scheinman, Frederick WK Tam, Rajesh V Thakker, Robert J Unwin and Oliver Wrong

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Figure 1.

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Estimated glomerular sieving coefficients for 12 plasma proteins versus molecular weight. Data are from Table 1; mean (plusminus SEM) of five determinations based on results from each of five patients with Dent's disease are shown. See Molecular size, charge and glomerular sieving for discussion of the anomalous behavior of alpha1-acid glycoprotein (alpha1AG) and beta2-glycoprotein-I (beta2GI). Abbreviations are: RBP, retinol-binding protein; alpha2m, alpha2-microglobulin; TSH, thyroid-stimulating hormone; ZAG, zinc-alpha2-globulin; DBP, vitamin D-binding protein; TTR, transthyretin; ALB, albumin; TRF, transferrin; IgG, immunoglobulin G.

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