Kidney International (1974) 6, 263–271; doi:10.1038/ki.1974.112
Phylogeny of the renal effects of angiotensin
Hirofumi Sokabe1
1Department of Pharmacology, Toho University School of Medicine, Tokyo, Japan
Correspondence: Dr Hirofumi Sokabe, Department of Pharmacology, Jichi Medical School, Minamikawachi-machi, Tochigi-ken, 329-04 Japan.
Received 10 May 1974.
Top of pageAbstract
The phylogenetic approach in studying hormonal actions on the kidney is important for the following reasons among others: 1) phylogenetic study of renal function has proved illuminating in the past; 2) nephron structures and functions are simpler in some non-mammalian vertebrates, and it may be easier to analyze hormonal actions on the kidney in these animals; 3) endocrine systems are different among various vertebrates, and their roles may be elucidated through comparison; 4) evolution of hormonal function has occurred, and to pursue it may be useful in determining the character of hormonal action, especially in higher vertebrates; and 5) vertebrates live in a wide variety of external environments, while the internal environment is usually kept in a narrow range. Since the kidney is a key organ for homeostasis of the internal environment, comparison of hormonal regulations of renal functions under various conditions may be instructive.
Top of pageReferences
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