Kidney International

FIGURE 2

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Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase

Mladen Knotek, Boris Rogachev, Wei Wang, Tevfik Ecder, Vyacheslav Melnikov, Patricia E Gengaro, Matthew Esson, Charles L Edelstein, Charles A Dinarello and Robert W Schrier

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Figure 2.

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Effect of TNFsRp55 (10 mg/kg IP) on renal function in wild-type mice. Mice were pretreated with TNFsRp55 for one hour before the administration of 5 mg/kg intraperitoneal endotoxin. GFR (A) and RPF (B) were determined 16 hours thereafter. Data are expressed as mean plusminus SEM, N = 6. *P < 0.05 vs. Control; §P < 0.05 vs. LPS, by ANOVA.

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