FIGURE 9
FROM:
Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure
Bernardo Rodríguez-Iturbe, Héctor Pons, Yasmir Quiroz, Katherine Gordon, Jaimar Rincón, Maribel Chávez, Gustavo Parra, Jaime Herrera-Acosta, Dulcenombre Gómez-Garre, Raquel Largo, Jesus Egido and Richard J Johnson
BACK TO ARTICLEFigure 9.
Structural changes, proliferative activity, and lymphocyte infiltration. (A) Structural changes (PAS staining) found at the end of angiotensin infusion (2 weeks) in the Ang II group present focal damage, including tubular dilation and sloughing (arrows) and areas of interstitial sclerotic widening (arrowheads). (B) A biopsy section from a rat from the Ang II + MMF group appears essentially normal. Proliferative activity as shown by PCNA-positive cells (anti-PCNA staining, avidin-biotin-peroxidase technique) at the end of angiotensin infusion is more pronounced in the Ang II group (C) than in the Ang II + MMF group (D); PCNA-positive cells are infiltrating cells, while the resident glomerular and tubular cells are negative. T-lymphocyte infiltration (staining with anti-CD5 mAb) in the Ang II group (E) is reduced by MMF treatment (F).
