FIGURES AND TABLES

Figure 1.

Conversion of dopamine to 5-S-cysteinyl dopamine (CYS-DA; ) by activated neutrophils. Dopamine (DA; 1 mol/L, ) was incubated with cysteine (Cys 1 mmol/L) for 30 minutes alone or in the presence of 10⁷ neutrophils (WBC)/mL. Zymogen was added to activate the neutrophils. Neutrophils significantly increased CYS-DA production and disappearance of dopamine (P = 0.03, ANOVA). Activating the WBC with zymogen increased dopamine removal (P = 0.03) but did not significantly increase CYS-DA production (N = 3).

Figure 2.

Unconjugated 5-S-cysteinyl dopamine (CYS-DA) expressed as a percentage of unconjugated dopamine (DA) in the plasma of patients undergoing dopamine treatment for acute illness. The percentage of CYS-DA/DA relative to the leukocyte count (WBC; A) is 7.6 + 0.36 WBC, and relative to the duration of dopamine treatment (days; B) is %CYS-DA/DA = 3.9 + 4.4 days, r = 0.38. The lines indicate the regression equation and 95% confidence limits.

Table 1 - Plasma catecholamines metabolites after 30 minutes of dopamine infusion with and without endotoxin.

Table 2 - Plasma catecholamines metabolites after 300 minutes of dopamine infusion with and without endotoxin.

Table 3 - Effect of endotoxin on urine catecholamine excretion during the fourth hour of dopamine infusion.

Table 4 - Catecholamine metabolites in cerebrospinal collected during dopamine infusion with and without endotoxin.

Table 5 - 5-S-cysteinyl dopamine in plasma of patients receiving intravenous dopamine.