FIGURE 2

(A ) A low power view of ORG shows focal segmental glomerulosclerosis and glomerulomegaly. There is minimal focal tubular atrophy (PAS, 100). (B) A hypertrophied glomerulus contains two discrete lesions of segmental sclerosis, one in the perihilar region and one in the peripheral tuft, with hyalinosis and adhesion to Bowman's capsule (PAS, 250). (C) A case of ORG with a massively hypertrophied glomerulus containing a peripherally situated discrete lesion of segmental sclerosis (PAS, 250). (D) A glomerulus with mild "diabetoid" changes characterized by mild mesangial sclerosis, mild diffuse glomerular basement membrane thickening, and glomerulomegaly from a patient with ORG and no clinical history of diabetes mellitus (PAS, 300). (E) By electron microscopy, diffuse glomerular basement membrane thickening and mild mesangial sclerosis are seen in this case of ORG without clinical evidence of diabetes (2,500). (F) A typical electron microscopic view of a glomerulus in ORG shows minimal foot process effacement despite nephrotic range proteinuria (2,500). (G and H) There is marked glomerular hypertrophy in ORG (G) compared to an age- and sex-matched normal control (H) (PAS, 300).