TABLE 3

FROM:

Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy

Peter M Jehle, Antje Ostertag, Klaus Schulten, Walter Schulz, Daniela R Jehle, Sylvia Stracke, Roman Fiedler, Heinz J Deuber, Frieder Keller, Bernhard O Boehm, David J Baylink and Subburaman Mohan

Table 3. Clinical data and IGF system components of HD patients with mixed uremic bone disease with or without histological signs of osteopenia

HD patients with mixed uremic bone disease	With osteopenia N = 17	Without osteopenia N = 11
Clinical data
Age years	523 [28–74]	485 [33–71]
Duration of CRF years	8.51.5 [1–28]	9.62.4 [0.5–25]
Duration of dialysis years	3.80.6 [0.5–8]	3.10.5 [0.8–5]
Creatinine 58–110 mol/L	62060 [446–1120]	70784 [370–1153]
Bone markers
PTH 11–54 pg/mL	27561 [14–630]	340113 [2–1290]
B-ALP 7–17 ng/mL	112.1 [1–32]	276.5 [8–81]b
OSC 11–48 ng/mL	314.6 [9–83]	488 [8–75]a
PICP 40–200 ng/mL	19520 [83–406]	23220 [92–357]
25-D3 10–60 ng/mL	165 [3–60]	224 [16–49]
IGF system components
Free IGF-I 0.94–9.4 ng/mL	2.140.3 [0.2–2.5]	3.030.3 [0.3–4.4]
IGF-I 45–288 ng/mL	16318 [44–286]	19833 [53–412]
IGF-II 324–582 ng/mL	90743 [580–1144]	93770 [422–1125]
IGFBP-1 0.1–17 ng/mL	283.8 [11.8–64]	3510 [4–112]
IGFBP-2 121–1172 ng/mL	2484134 [1527–3616]	1946188 [1111–2970]a
IGFBP-3 1140–4968 ng/mL	4543695 [643–10779]	4862509 [1841–8428]
IGFBP-4 160–796 ng/mL	92882238 [3619–21365]	62611052 [1574–12616]a
IGFBP-5 319–713 ng/mL	26817 [137–344]	32033 [185–509]a
IGFBP-6 41–198 ng/mL	2673214 [794–3685]	2787411 [643–5229]

 Data are mean values [range]SEM; reference values are in parentheses.

^a  P < 0.05

^b  P < 0.005