Kidney International - Table 2 for article: Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy

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Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy

Peter M Jehle, Antje Ostertag, Klaus Schulten, Walter Schulz, Daniela R Jehle, Sylvia Stracke, Roman Fiedler, Heinz J Deuber, Frieder Keller, Bernhard O Boehm, David J Baylink and Subburaman Mohan

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Table 2. Serum levels of IGF-I, free IGF-I, IGF-II and IGFBP-1 to -6 in patients with different stages of chronic renal failure (CRF), end-stage renal failure (ESRF) treated by hemodialysis (HD), peritoneal dialysis (PD) or renal transplantation (RTX) compared to age-matched healthy control subjects (Controls) and patients with primary hyperparathyroidism (pHPT)

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	Controls	pHPT	CRF I°	CRF II°	CRF III°	ESRF/HD	ESRF/PD	ESRF/RTX
N ( = 431)	87	25	29	48	37	148	27	30
Age years	573	603	562.6	562.6	572.5	563	453	472
IGF-I	13515 [45–288]	n.d.	9923 [69–129]^a	14925 [63–216]	12327 [48–231]	17166 [44–412]	n.d.	n.d.
Free IGF-I	2.71.3 [0.94–9.4]	4.10.7 [0.2–13.7]^a	4.20.8 [0.3–17]^a	2.90.3 [0.2–9.1]	3.60.5 [0.4–11.7]	2.90.3 [0.2–17.8]	2.20.6 [0.2–15.7]	4.70.8 [0.2–19.7]^a, ^d
IGF-II	46137 [324–582]	n.d.	51946 [408–720]	51776 [354–774]	50148 [306–660]	925228 [432–1546]^a	n.d.	n.d.
IGFBP-1	2.32.1 [0.1–17]	8.12.2 [0.2–66]^a	15.65 [1–104]^a, ^b	254 [2–91]^a, ^b	264 [3–80]^a, ^b	33.23 [0.9–172]^a, ^b	25.76 [1–98]^a, ^b	17.93 [1.4–60]^a, ^b
IGFBP-2	47421 [121–1172]	90791 [290–1667]^a	1428185 [452–2771]^a	1847108 [873–3287]^a, ^b	2491171 [908–4101]^a, ^b	291497 [984–6615]^a, ^b	3561207 [793–5216]^a, ^b	1428123 [428–2831]^a, ^b, ^d
IGFBP-3	3087230 [1140–4968]	3853192 [2347–6519]^a	4610431 [1100–11734]^a	5120406 [1747–17817]^a	5267457 [1607–11355]^a	5269221 [1083–15758]^a	97211695 [2673–45120]^a, ^b, ^c	5349553 [1257–14533]^a, ^d
IGFBP-4	39630 [160–796]	43034 [185–872]	1218227 [263–6364]^a, ^b	1937207 [693–7559]^a, ^b	2343245 [966–8878]^a, ^b	4557410 [764–40749]^a, ^b, ^c	76071546 [1165–36692]^a, ^b, ^c	1442146 [433–3670]^a, ^b, ^d
IGFBP-5	45444 [319–713]	29821 [113–493]^a	31317 [149–500]^a	28419 [131–763]^a	32022 [151–773]^a	36261 [84–662]	31524 [109–544]^a	31921 [124–570]^a
IGFBP-6	995 [41–198]	36772 [67–1313]^a	891131 [201–2041]^a, ^b	98683 [185–2917]^a, ^b	109754 [645–1596]^a, ^b	166679 [316–6345]^a, ^b, ^c	2497142 [1006–4240]^a, ^b, ^c	75572 [273–1474]^a, ^b, ^d

Data are mean values [range] plusminus SEM. n.d. is not determined.

^a P < 0.05 vs. controls

^b P < 0.05 vs. pHPT

^c P < 0.05 vs. CRF III°

^d P < 0.05 vs. PD

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TABLE 2

Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy