Division of Nephrology, Royal Victoria Hospital, Montreal, Quebec, Canada

Correspondence: Andrey V. Cybulsky, M.D., Division of Nephrology, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1. E-mail: cybulsky@pathology.lan.mcgill.ca

Abstract

Extracellular matrix as a determinant of signaling responses in glomerular epithelial cells. Glomerular epithelial cell proliferation occurs in renal diseases such as membranous nephropathy and crescentic glomerulonephritis. To understand the growth factors responsible for the proliferative response and inflammation of these cells, we have examined the effects of extracellular matrix on the regulation of glomerular epithelial cell proliferation and phospholipid turnover, as well as the pathophysiological consequences of this intricate process.