Laboratory Investigation

Kidney International (1974) 5, 271–278; doi:10.1038/ki.1974.36

Dynamics of glomerular ultrafiltration: VI. Studies in the primate

David A Maddox1, William M Deen1, Barry M Brenner1, with the technical assistance of Julia L Troy1 and Robert W Surface1

1Departments of Medicine, Veterans Administration Hospital and the University of California, San Francisco, California

Correspondence: Dr Barry M Brenner, Veterans Administration Hospital, 4150 Clement Street, San Francisco, California 94121, U.S.A.

Received 24 September 1973; Revised 24 October 1973.

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Abstract

Dynamics of glomerular ultrafiltration: VI. Studies in the primate. Pressures and flows were measured in accessible surface glomeruli of the squirrel monkey under conditions of normal hydropenia. Mean glomerular capillary hydrostatic pressure and the mean glomerular transcapillary hydrostatic pressure difference (DeltaP) averaged approximately 45 mm Hg and 35 mm Hg, respectively. These findings are in close accord with recent direct estimates in the rat. The net driving force for ultrafiltration was found to decline from a maximum value of about 12 mm Hg at the afferent end of the glomerular capillary network essentially to zero by the efferent end, indicating that, in the monkey as in the rat, filtration pressure equilibrium is achieved under normal hydropenic conditions. The monkey differs from the rat in one important respect, however, in that, as has long been recognized, the monkey tends to have higher systemic total plasma protein concentrations (CA) than the rat. This is of interest since monkey, like man, is found to have lower filtration fractions than the rat. Since DeltaP is found to be essentially similar in monkey and rat, and since, at filtration pressure equilibrium, filtration fraction is determined by DeltaP and CA, these observed differences in filtration fraction between rodent and primate must therefore be due to these differences in CA.

Dynamique de l'ultrafiltration glomérulaire : VI. Etudes chez le primate. Les pressions et les débits ont été mesurés dans les glomérules superficiels accessibles du sagouin dans des conditions d'hydropénie physiologique. La pression hydrostatique capillaire glomérulaire moyenne et la différence de pression hydrostatique transcapillaire glomérulaire (DeltaP) sont approximativement de 45 mm Hg et 35 mm Hg, respectivement. Ces constatations sont en accord étroit avec les mesures directes récentes chez le rat. La force motrice nette de l'ultrafiltration décroît d'une valeur maximum de 12 mm Hg à l'extrémité afférente du réseau capillaire glomérulaire à pratiquement zéro à l'extrémité éfférente, ce qui indique, chez le sagouin comme chez le rat, que l'équilibre de pression de filtration est obtenu dans les conditions d'hydropénie normale. Le sagouin diffère du rat à un égard important, cependant, en ce qu'il tend à avoir une concentration systémique plus élevée de protéines plasmatiques (CA), ainsi que cela est connu de longue date. Ce fait est important dans le mesure où chez le sagouin, comme chez l'homme, des fractions de filtration plus faibles que celle du rat ont été obtenues. Du fait que des valeurs très semblables de DeltaP ont été obtenues chez le sagouin et le rat et puisqu'à l'équilibre de pression de filtration la fraction filtrée est déterminée par DeltaP et CA les différences observées dans les fractions de filtration entre rongeurs et primates doivent donc être liées à ces différences de CA.

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