Mechanism and Regulation of Water Transport

Kidney International (1996) 49, 1718–1723; doi:10.1038/ki.1996.254

The aquaporin family of water channels in kidney: An update on physiology and pathophysiology of aquaporin-2

Søren Nielsen, David Marples, Jørgen Frøklær, Mark Knepper and Peter Agre

Department of Cell Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark; Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, and Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Correspondence: Søren Nielsen MD PhD, Department of Cell Biology, Institute of Anatomy, DK-8000 Aarhus C, University of Aarhus, Aarhus, Denmark. E-mail: SN@ANA.AAU.DK

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Abstract

The aquaporin family of water channels in kidney: An update on physiology and pathophysiology of aquaporin-2. The long-standing problem of membrane water transport has been advanced by the recognition of a new family of water transport proteins, the "aquaporins" [1–3]. Not surprisingly, water transport is a major process in kidney physiology, and the biology of aquaporins is most thoroughly understood in that organ. We reviewed in detail the status of aquaporins in the kidney only one year ago [4], but the subsequent progress has dictated the need for an update. This seems especially appropriate in honor of the 100th birthday of Homer Smith, the pioneer whose foresight initiated this field.

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References

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