Kidney International (1992) 41, 877–882; doi:10.1038/ki.1992.134
Prevalence of raised sodium-lithium countertransport activity in type 1 diabetic patients
José B Lopes de Faria1, Rogério Friedman1, Taimur Tariq1 and GianCarlo Viberti1
1Unit for Metabolic Medicine, United Medical and Dental Schools, Guy's Hospital, London, England, United Kingdom
Correspondence: Prof G C Viberti, Unit for Metabolic Medicine, 4th Floor, Hunt's House, Guy's Hospital, London, SEI 9RT, England, United Kingdom.
Top of pageAbstract
Prevalence of raised sodium-lithium countertransport activity in type 1 diabetic patients. The prevalence of raised Na+/Li+ countertransport (CT) activity (>0.41 mmol/liter RBC/hr) was assessed in 185 consecutive insulin-dependent diabetic patients attending an outpatient diabetic clinic. Normoalbuminuria was defined as an overnight albumin excretion rate (AER) of <20
g/min (N = 121), microalbuminuria as AER between 20 and 150
g/min (N = 35) and macroalbuminuria as AER
150
g/min (N = 29). The prevalence of elevated Na+/Li+CT (>0.41 mmol/liter RBC/hr) was 21.5, 42.8 and 51.7% (P = 0.0005), in patients with normo-, micro- and macroalbuminuria, respectively. In the whole group, Na+/Li+CT was significantly related to mean blood pressure (MBP; rs = 0.37, P < 0.001) and AER (rs = 0.38, P < 0.001). In a multiple regression analysis the significant correlates AER, as a continuous variable, or of proteinuria (micro + macroalbuminuria), as a categorical variable, were Na+/Li+CT, MBP, duration of diabetes and glycosylated hemoglobin (HbAl). The frequency of normoalbuminuric patients with high Na+/Li+CT activity fell with duration of diabetes. The risk of proteinuria was significantly greater in patients with raised Na+/Li+CT compared to those with Na+/Li+CT within the normal range (odds ratio 3.8, 95% CI, 1.9 and 7.8). A relative excess of patients with proteinuria (micro + macroalbuminuria) was found in the group with elevated Na+/Li+CT and HbAl above the median value (8.05%) of the whole population (
2 = 9.7, P < 0.002). Elevated Na+/Li+CT activity is more prevalent in IDDM patients with proteinuria and is rare in long-standing normoalbuminuric patients; the risk of proteinuria increases with increasing Na+/Li+CT rates; blood glucose control and Na+/Li+CT appear to interact in determining proteinuria.
Top of pageReferences
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