Editorial Review

Kidney International (1991) 40, 989–996; doi:10.1038/ki.1991.306

Polycystic kidney disease: Clues to pathogenesis

Patricia A Gabow1

1Denver, Colorado, USA

Correspondence: Patricia Gabow MD, Box C283, University of Colorado, 4200 East Ninth Avenue, Denver, Colorado 80262, USA.

Received 17 October 1990; Revised 20 February 1991; Accepted 22 February 1991.

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Abstract

Autosomal-dominant polycystic kidney disease (ADPKD), largely neglected for several decades, has emerged in recent years as the renal disease most likely to be understood from the gene to the patient. Major breakthroughs have occurred in the genetics of the disorder and new experimental data is providing insights in the pathobiology of cyst formation (Table 1).

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