Renal Regulation of Extracellular Fluid Composition Symposium in Honor of Donald W. Seldin, M.D.

Kidney International (1990) 38, 679–686; doi:10.1038/ki.1990.259

Sodium and potassium transport by the collecting duct

John B Stokes1

1Laboratory of Epithelial Transport, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA

Correspondence: Dr John B Stokes, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

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Abstract

This review covers aspects of Na and K transport along the three major regions of the collecting duct: the cortical collecting duct (CCD), the outer medullary collecting duct (OMCD), and the inner medullary collecting duct (IMCD). The basic cell models that have been developed over the past several years are included with an attempt to integrate some of the newer observations on specific transport processes and their regulation. Heterogeneity along the collecting duct is emphasized as are species differences insofar as they are known. The normal mechanisms of Na and K transport are presented in the context of their long-term regulation by steroid hormones. The enormous increase in the understanding of the subject over the past several years precludes a detailed review of collecting duct function and its hormonal regulation. Mechanisms of Na transport regulation in epithelial models of the collecting duct are mentioned to the extent that they provide illustrative mechanisms. The lessons and principles derived from such model systems form a critical portion of the integrated understanding of distal nephron and collecting duct Na transport.

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References

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