Clinical Investigation

Kidney International (1990) 37, 965–970; doi:10.1038/ki.1990.72

Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis

David R W Jayne, Philip D Marshall, Sally J Jones and C Martin Lockwood

Office of the Regius Professor of Physic, Clinical Medical School, Addenbrookes Hospital, Cambridge, CB2 2QQ, United Kingdom

Correspondence: Dr D R W Jayne, Office of the Regius Professor of Physic, Clinical Medical School, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom.

Received 6 April 1989; Revised 8 September 1989; Accepted 5 October 1989.

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Abstract

Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis. The incidence of autoantibodies to glomerular basement membrane (AGBMA) and neutrophil cytoplasmic antigens (ANCA) in the initial sera of 889 consecutive patients with a suspected diagnosis of rapidly progressive glomerulonephritis, was determined by prospective study. Forty-seven (5%) were positive for AGBMA alone, 246 (28%) were positive for ANCA alone, 576 (65%) had neither autoantibodies while 20 (2%) had both. Clinical and pathological data collected from patients with both autoantibodies suggested the coexistence of anti-glomerular basement membrane disease and systemic vasculitis. Together, assays for AGBMA and ANCA are important in the diagnosis and management of rapidly progressive glomerulonephritis and may help its further classification.

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