Laboratory Investigation

Kidney International (1988) 34, 487–493; doi:10.1038/ki.1988.207

Immunological aspects of acute ureteral obstruction: Immune cell infiltrate in the kidney

George F Schreiner, Kevin P G Harris, Mabel L Purkerson and Saulo Klahr

Renal Division, Department of Medicine, and the Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA

Correspondence: George Schreiner MD, Box 8126, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, 63110, USA.

Received 4 December 1987; Revised 24 May 1988.

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Abstract

Immunological aspects of acute ureteral obstruction: Immune cell infiltrate in the kidney. Kidneys from rats subjected to bilateral ureteral obstruction (BUO), unilateral ureteral obstruction (UUO) and UUO with subsequent release were analyzed for leukocyte infiltration. A time-dependent influx of leukocytes, predominantly macrophages and suppressor T lymphocytes, occurred in both the cortex and medulla following obstruction, and disappeared with release of the obstruction. Glomerular macrophages declined following obstruction but increased to levels above control following release. The influx of leukocytes following obstruction was paralleled by an increase in thromboxane B2 excretion by the kidney and coincided with a decrease in glomerular filtration rate (GFR). This would suggest that an influx of immune cells is a prominent feature of the acute renal response to ureteral obstruction. These cells may modulate some of the post-obstructive alterations in renal function via the production of vasoactive substances, such as thromboxane A2.

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