Symposium on Methods in Renal Research

Kidney International (1986) 30, 255–263; doi:10.1038/ki.1986.177

Quantitation of exogenous and endogenous components of glomerular immune deposits

David J Salant1, Andrey V Cybulsky1 and Irwin D Feintzeig1

1Evans Memorial Department of Clinical Research and Department of Medicine, University Hospital, Boston University Medical Center, Boston, Massachusetts, USA

Correspondence: Dr David J Salant, Renal Section, University Hospital, 75 E. Newton Street, Boston, Massachusetts 02118, U.S.A.

Received 20 February 1986.

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References

  1. Yalow RS, Berson SA: Immunoassay of endogenous insulin in man. J Clin Invest 39:1157–1175, 1960 | PubMed | ISI | ChemPort |
  2. Johnson A, Day ED, Pressman D: The effect of iodination on antibody activity. J Immunol 84:213–220, 1960
  3. McConahey PJ, Dixon FJ: A method of trace iodination of proteins for immunologic studies. Int Arch Allergy 29:185–189, 1966 | PubMed | ISI | ChemPort |
  4. Salant DJ, Darby C, Couser WG: Experimental membranous nephropathy. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. J Clin Invest 66:71–81, 1980 | PubMed | ISI | ChemPort |
  5. Pressman D, Day ED, Blau M: The use of paired labelling in the determination of tumor localizing antibodies. Cancer Res 17:845–850, 1957 | PubMed | ChemPort |
  6. Wilson CB, Dixon FJ: Antigen quantitation in experimental immune complex glomerulonephritis. I. Acute serum sickness. J Immunol 105:279–290, 1970 | PubMed | ChemPort |
  7. Madaio MP, Salant DJ, Cohen AJ, Adler S, Couser WG: Comparative study of in situ immune deposit formation in active and passive Heymann nephritis. Kidney Int 23:498–505, 1983
  8. Groggel GC, Adler S, Rennke HG, Couser WG, Salant DJ: Role of the terminal complement pathway in experimental membranous nephropathy in the rabbit. J Clin Invest 72:1948–1957, 1983 | PubMed | ChemPort |
  9. Groggel GC, Salant DJ, Darby C, Rennke HG, Couser WG: Role of terminal complement pathway in the heterologous phase of antiglomerular basement membrane nephritis. Kidney Int 27:643–651, 1985 | Article | PubMed | ISI | ChemPort |
  10. Adler S, Baker P, Pritzl P, Couser WG: Effect of alterations in glomerular charge on deposition of cationic and anionic antibodies to fixed glomerular antigens in the rat. J Lab Clin Med 166:1–11, 1985
  11. Haakenstad AO, Mannik M: The disappearance kinetics of soluble immune complexes prepared with reduced and alkylated antibodies and with intact antibodies in mice. Lab Invest 35:283–292, 1976 | PubMed | ChemPort |
  12. Hebert LA, Allhiser CL, Koethe SM, Rodey GE: Uptake of immune complexes by renal glomeruli and renal non-glomerular tissue. J Clin Lab Immunol 1:99–105, 1978
  13. Mauer SM, Fish AJ, Blau EB, Michael AF: The glomerular mesangium: I. Kinetic studies of macromolecular uptake in normal and nephrotic rats. J Clin Invest 51:1092–1101, 1972
  14. Raij L, Keane WF, Osswald H, Michael A: Mesangial function in ureteral obstruction in the rat. Blockade of the afferent limb. J Clin Invest 64:1204–1212, 1979
  15. Jensen RH, Greenspan JS, Moore D, Talal N, Roubinian JR: Quantitative immunofluorescence microscopy of renal glomeruli from mice exhibiting murine lupus erythematosis. J Immunol Methods 42:343–353, 1981
  16. Barnes JL, Venkatachalam MA: Enhancement of glomerular immune complex deposition by a circulating polycation. J Exp Med 160:286–293, 1984
  17. Abrahamson DR, Hein A, Caulfield JP: Laminin in glomerular basement membranes of aminonucleoside nephrotic rats. Increased proteinuria induced by antilaminin immunoglobulin G. Lab Invest 49:38–7, 1983
  18. Kronvall G, Seal US, Finstad J, Williams RC: Phylogenetic insight into evolution of mammalian Fc fragment of globulin using staphylococcal protein A. J Immunol 104:140–147, 1970
  19. Axen R, Porath J, Ernback S: Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides. Nature 214:1301–1304, 1967
  20. Murphy RF: Immunoaffinity chromatography. Biochem Soc Trans 2:1298–1302, 1974
  21. Mendrick DL, Rennke HG, Cotran RS, Springer TA, Abbas AK: Methods in laboratory investigation. Monoclonal antibodies against rat glomerular antigens: production and specificity. Lab Invest 49:107–117, 1983 | PubMed | ISI | ChemPort |
  22. Abrahamson DR, Caulfield JP: Distribution of laminin within rat and mouse renal, splenic, intestinal, and hepatic basement membranes identified after the injection of heterologous antilaminin IgG. Lab Invest 52:169–181, 1985
  23. Cochrane CG: Mediation systems in neutrophil–independent immunologic injury of the glomerulus, in Immunologic Mechanisms of Renal Disease edited by Wilson CB, Brenner BM, Stein JH, New York, Churchill Livingstone, 1979, p. 106
  24. Salant DJ, Belok S, Madaio MP, Couser WG: A new role for complement in experimental membranous nephropathy. J Clin Invest 66:1339–1350, 1980 | PubMed | ISI | ChemPort |
  25. Madaio MP, Salant DJ, Adler S, Darby C, Couser WG: Effect of antibody charge and concentration on glomerular deposition of anti-GBM antibody. Kidney Int 26:397–403, 1984
  26. Feintzeig ID, Dittmer JE, Cybulsky AV, Salant DJ: Antibody, antigen and glomerular capillary wall charge interactions: Influence of antigen location on in situ immune complex formation. Kidney Int 29:649–657, 1986
  27. Gauthier VJ, Mannik M, Striker GE: Effect of cationized antibodies in preformed immune complexes on deposition and persistence in renal glomeruli. J Exp Med 156:766–777, 1982 | Article | PubMed | ChemPort |
  28. Pinckard RN: Equilibrium dialysis and preparation of hapten conjugates, in Handbook of Experimental Immunology, third edition, edited by Weir DM, Oxford, Blackwell Scientific Publications, 1978, vol 1, p. 171
  29. Vaerman JP, Lebacq–Verheyden AM, Scolari L, Heremans JF: Further studies of single radial immunodiffusion. II. The reversed system: Diffusion of antibodies in antigen-containing gels. Immunochemistry 6:287–293, 1969
  30. Tan–Wilson AL, Rightmire BR, Wilson KA: Determination of relative antigen–antibody avidities by radial immunodiffusion. J Immunol Methods 61:99–106, 1983
  31. Tack BF, Dean J, Eilat D, Lorenz PE, Schechter AN: Tritium labelling of proteins to high specific radioactivity by reductive methylation. J Biol Chem 255:8842–8847, 1980 | PubMed | ISI | ChemPort |
  32. Soini E: Radioisotope counting techniques for analytical applications in biology and medicine. Science Tools 25:38–48, 1978
  33. Koshland ME, Engleberger FM, Gaddone S: Identification of tyrosine at the active site of anti-p-azobenzenearsonic acid antibody. J Biol Chem 238:1349–1352, 1963
  34. Levy NL, Dawson JR: Radiolabelling of immunoglobulin without loss of antibody activity—use of 14C-phenyl-isothiocyanate with human cytotoxic antibody. J Immunol 116:1526–1531, 1976
  35. Greenwood FC, Hunter WL, Glover JJ: The preparation of 131I-labelled growth hormone of high specific activity. Biochem J 89:114–123, 1963 | PubMed | ISI | ChemPort |
  36. Miyachi Y, Vaitukaitis JL, Nieschlag E, Lipsett MB: Enzymatic radioiodination of gonadotropins. J Clin Endocrinol Metab 34:23–28, 1972
  37. McFarlane AS: Metabolism of plasma proteins, in Mammalian Protein Metabolism, edited by Munro HN, Allison JB, New York, Academic Press, 1964, p. 297
  38. Vaitukaitis JL: Specific human chorionic gonadotropin assay, in Methods of Hormone Radioimmunoassay, second edition, edited by Jaffe BM, Behrman HR, New York, Academic Press, 1979, p. 817
  39. Pressman D, Keighley G: The zone of activity of antibodies as determined by the use of radioactive tracers; the zone of activity of nephrotoxic antikidney serum. J Immunol 59:141–146, 1948 | ISI | ChemPort |
  40. Pressman D: The zone of localization of antibodies. III. The specific localization of antibodies to rat kidney. Cancer 2:697–700, 1949
  41. Pressman D, Eisen H, Fitzgerald P: The zone of localization of antibodies VI. The rate of localization of anti-mouse kidney serum. J Immunol 64:281–287, 1950
  42. Unanue ER, Dixon FJ: Experimental glomerulonephritis. V. Studies on the interaction of nephrotoxic antibodies with tissues of the rat. J Exp Med 121:697–714, 1965 | Article | PubMed | ChemPort |
  43. Strassberg J, Paule J, Gonick HC, Maxwell MH, Kleeman CR: The quantitative estimation of perfusible glomeruli and the collagen and noncollagen nitrogen of the normal kidney. Nephron 4:384–393, 1967
  44. Barratt LJ, Wallin JD, Rector FC, Seldin DW: The influence of volume expansion on single nephron filtration rate and plasma flow in the rat. Am J Physiol 224(Suppl 3):643–650, 1973
  45. Neale TJ, Couser WG, Salant DJ, Lowenstein LM, Wilson CG: Specific uptake of Heymann's nephritic kidney eluate by rat kidney. Studies in vivo and in isolated perfused kidneys. Lab Invest 46:450–453, 1982
  46. Oite T, Batsford SR, Mihatsch MJ, Takamiya H, Vogt A: Quantitative studies of in situ immune complex glomerulonephritis in the rat induced by planted cationized antigen. J Exp Med 155:460–474, 1982 | Article | PubMed | ChemPort |
  47. Hassid A, Konieczkowski M, Dunn MJ: Prostaglandin synthesis in isolated rat glomeruli. Proc Natl Acad Sci USA 76:1155–1159, 1979 | PubMed | ChemPort |
  48. Border WA, Ward HJ, Kamil ES, Cohen AH: Induction of membranous nephropathy in rabbits by administration of an exogenous cationized antigen. Demonstration of a pathogenetic role for electrical charge. J Clin Invest 69:451–461, 1982
  49. Blantz RC, Tucker BJ, Gushwa LC, Peterson OW, Wilson CB: Glomerular immune injury in the rat: The influence of angiotensin II and alpha-adrenergic inhibitors. Kidney Int 20:452–461, 1981 | PubMed | ISI | ChemPort |
  50. Simpson IJ, Amos N, Evans DJ, Thomson NM, Peters DK: Guinea pig nephrotoxic nephritis I. The role of complement and polymorphonuclear leukocytes and the effect of antibody subclass and fragments in the heterologous phase. Clin Exp Immunol 19:499–511, 1975 | PubMed | ChemPort |
  51. Tucker BJ, Gushwa LC, Wilson CB, Blantz RC: Effect of leukocyte depletion on glomerular dynamics during acute glomerular immune injury. Kidney Int 28:28–35, 1985
  52. Tipping PG, Holdsworth SR: Effect of cyclosporin A on antibody-induced experimental glomerulonephritis. Nephron 40:201–205, 1985 | PubMed | ISI | ChemPort |
  53. Waldmann TA, Strober W: Metabolism of immunoglobulins. Progr Allergy 13:1–110, 1969
  54. Blantz RC, Tucker BJ, Wilson CB: The acute effects of antiglomerular basement membrane antibody upon glomerular filtration in the rat. J Clin Invest 61:910–921, 1978
  55. Ichikawa I, Hoyer JR, Seiler MW, Brenner BM: Mechanism of glomerulotubular balance in the setting of heterogenous glomerular injury. J Clin Invest 69:185–198, 1982 | PubMed | ISI |
  56. Lianos EA, Andres GA, Dunn MJ: Glomerular prostaglandin and thromboxane suynthesis in rat nephrotoxic serum nephritis. J Clin Invest 72:1439–1449, 1983 | PubMed | ChemPort |
  57. Deen WM, Satvat B: Determinants of the glomerular filtration of proteins. Am J Physiol 241:F162–F170, 1981 | PubMed | ISI | ChemPort |
  58. Hebert LA, Allhiser CL, Koethe SM: Some hemodynamic determinants of immune complex trapping by the kidney. Kidney Int 14:452–465, 1978
  59. Ward DM, Blantz RC: Effects of angiotensin II on the glomerular mesangial uptake of macromolecules in rats. (abstract) Clin Res 29:479A, 1981
  60. Miyazawa H, Salant D, Yared A, Purkerson M, Klahr S, Ichikawa I: Influence of age, sex and diet on the glomerular response to antiglomerular basement membrane antibody (aGBM). (abstract) Kidney Int 27:247, 1985
  61. Unanue ER, Dixon FJ: Experimental glomerulonephritis VI. The autologous phase of nephrotoxic serum nephritis. J Exp Med 121:715–726, 1965 | PubMed | ISI | ChemPort |
  62. Rennke HG, Cotran RS, Venkatachalam MA: Role of molecular charge in glomerular permeability: Tracer studies with cationic ferritins. J Cell Biol 67:638–646, 1975 | Article | PubMed | ISI | ChemPort |
  63. Caulfield JP, Farquhar MG: Distribution of anionic sites in glomerular basement membranes: Their possible role in filtration and attachment. Proc Natl Acad Sci USA 73:1646–1650, 1976 | PubMed | ChemPort |
  64. Vogt A, Rohrbach F, Shimizu F, Takamiya H, Batsford S: Interaction of cationized antigen with rat glomerular basement membrane. Kidney Int 23:27–35, 1982
  65. Bergman P, Kacenelenbogen R, Vizet A: Plasma clearance, tissue distribution and catabolism of cationized albumins with increasing isoelectric points in the rat. Clin Sci 67:35–43, 1984
  66. Gallo GR, Caulin–Glaser T, Emancipator SN, Lamm ME: Nephritogenicity and differential distribution of glomerular immune complexes related to immunogen charge. Lab Invest 48:353–362, 1983 | PubMed | ChemPort |
  67. Wilson CB, Dixon FJ: Quantitation of acute and chronic serum sickness in the rabbit. J Exp Med 134:7s–18s, 1971
  68. Talmage DW, Maurer PH: 131I labelled antigen precipitation as a measure of quantity and quality of antibody. J Infect Dis 92:288–300, 1953 | PubMed | ISI | ChemPort |
  69. Minden P, Farr RS: Ammonium sulphate method to measure antigen–binding capacity, in Handbook of Experimental Immunology, third edition, edited by Weir DM, Oxford, Blackwell Scientific Publications, 1978
  70. Scatchard G: The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51:660–672, 1946
  71. Haakenstad AV, Striker GE, Mannik M: The disappearance kinetics and glomerular deposition of small–latticed soluble immune complexes. Immunology 47:407–414, 1982 | PubMed | ChemPort |
  72. Bartolotti SR, Peters DK: Delayed removal of renal bound antigen in decomplemented rabbits with acute serum sickness. Clin Exp Immunol 32:199–206, 1978
  73. Raij L, Sibley RK, Keane WF: Mononuclear phagocytic system stimulation. J Lab Clin Med 98:558–567, 1981
  74. Barcelli U, Rademacher R, Ooi YM, Ooi BS: Modification of glomerular immune complex deposition in mice by activation of the reticuloendothelial system. J Clin Invest 67:20–27, 1981

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