Laboratory Investgation

Kidney International (1986) 30, 16–19; doi:10.1038/ki.1986.144

The renal action of atrial natriuretic peptide during control of glomerular filtration

John C Burnett Jr1, Terry J Opgenorth1 and Joey P Granger1

1Departments of Medicine and Physiology, Mayo Medical School, Rochester, Minnesota, USA

Correspondence: John C Burnett Jr MD, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Medical School, Rochester, Minnesota 55905, USA.

Received 17 May 1985; Revised 16 September 1985.

Top

Abstract

The renal action of atrial natriuretic peptide during control of glomerular filtration. Studies were performed in anesthetized dogs (N=7) to determine the effects of synthetic atrial natriuretic peptide (ANP) on sodium excretion in the presence and absence of control of glomerular filtration rate produced by suprarenal aortic clamping. Intrarenal infusion of synthetic atrial natriuretic peptide (0.3 microg/kg/min) significantly increased glomerular filtration rate from 29.3 plusminus3.0 to 43.2 plusminus4.4 ml/min, urinary sodium excretion from 20.1 plusminus10.3 to 223.3 plusminus52.3 microEq/min, fractional sodium excretion from 0.47 plusminus0.19 to 3.75 plusminus0.59%. In contrast, aortic clamping blocked the increase in glomerular filtration rate in association with an attenuated natriuresis. Urinary sodium excretion increased from 6.3 plusminus2.3 to 68.3 plusminus23.4 microEq/min and fractional sodium excretion increased from 0.15 plusminus0.04 to 0.90 plusminus0.30%. Despite this differential response in glomerular filtration rate and sodium excretion, whole kidney fractional delivery of sodium from the proximal tubule as estimated by the fractional excretion of lithium increased during both undamped (17.7 plusminus1.8 to 30.4 plusminus0.8%) and clamped (12.9 plusminus2.1 to 23.9 plusminus2.7%) periods. These studies demonstrate that atrial natriuretic peptide–induced natriuresis is importantly mediated by an increase in glomerular filtration rate and decrease in tubular reabsorption.

Top

References

  1. Burnett JC, Granger JP, Opgenorth TJ: Effects of synthetic atrial natriuretic factor on renal function and renin release. Am J Physiol 247:F863–F866, 1984 | PubMed | ChemPort |
  2. Maack T, Marion DN, Camargo MJ, Kleinert HD, Laragh JH, Vaughan ED, Atlas SA: Effects of auriculin–atrial natriuretic factor on blood pressure, renal function, and the renin–aldosterone system in dogs. Am J Med 77:1069–1075, 1984 | Article | PubMed | ChemPort |
  3. Beasley D, Malvin RL: Atrial extract increases glomerular filtration rate in vivo. Am J Physiol 248:F24–F30, 1985
  4. Sonnenberg J, Cupples WA, deBold AJ, Veress AT: Intrarenal localization of the natriuretic effect of cardiac atrial extract. Can J Physiol Pharmacol 60:1149–1152, 1982
  5. Petersen V, Hvidt S, Thomsen K, Schow M: Effect of prolonged thiazide treatment on renal lithium clearance. Br Med J 3:143–145, 1974
  6. Levy M, Starr NL: The mechanism of glucagon–induced natriuresis in dogs. Kidney Int 2:76–84, 1972
  7. Johannesen J, Lie M, Kul F: Effect of glycine and glucagon on glomerular filtration and renal metabolic rates. Am J Physiol 233:F61–F66, 1977
  8. Führ J, Kachzmarczyk J, Krüttgen CD: Eine einfache colorimetrische Methode zur Insulinbestimmung für Nierenclearanceuntersuchungen bei Stoffwechselgesunden und Diabetikern. Klin Wochenschr 33:729–730, 1955 | PubMed | ISI | ChemPort |
  9. Hayslett JP, Kashgarian M: A micropuncture study of the renal handling of lithium. Pflügers Arch 380:159–163, 1979
  10. Thomsen K, Holstein–Rathlow NH, Leyssac PP: Comparison of three measures of proximal tubular reabsorption: Lithium clearance, occlusion time, and micropuncture. Am J Physiol 241:F348–F355, 1981
  11. Thomsen K, Schow M: Renal lithium excretion in man. Am J Physiol 215:823–827, 1968
  12. Camargo MJF, Kleinert HD, Atlas SA, Sealey GE, Laragh JH, Maack T: Ca-dependent hemodynamic and natriuretic effect of atrial extract in isolated rat kidney. Am J Physiol 246:F447–F456, 1984 | PubMed | ISI | ChemPort |
  13. Huang CL, Lewichi J, Johnson LK, Cogan MG: Renal mechanisms of action of rat atrial natriuretic factor. J Clin Invest 75:769–774, 1985 | PubMed | ISI | ChemPort |
  14. Ichikawa I, Dunn BR, Troy JL, Maack T, Brenner BM: Influence of atrial natriuretic peptide on glomerular microcirculation in vivo. (abstract) Clin Res 33:487A, 1985
  15. Tremblay J, Gerzer R, Vinay P, Pang SC, Reliveau R, Hamet P: The increase of cGMP by atrial natriuretic factor correlates with the distribution of particulate guanylate cyclase. FEBS Lett 181:17–22, 1985 | Article | PubMed | ChemPort |
  16. Hammond TG, Yusufi ANK, Knox FG, Dousa TP: Administration of atrial natriuretic factor inhibits proximal Na-coupled solute transport. J Clin Invest 75:1983–1989, 1985
  17. Borenstein HB, Cupples WA, Sonnenberg H, Veress AT: The effect of a natriuretic atrial extract on renal haemodynamics and urinary excretion in anaesthetized rats. J Physiol London 334:133–140, 1983

Extra navigation

.
ADVERTISEMENT