Nephrology Forum

Kidney International (1985) 28, 845–855; doi:10.1038/ki.1985.207

The cellular renal response to respiratory acid-base disorders

Principal discussant: Qais Al-Awqati1

1Columbia University, College of Physicians and Surgeons, New York, New York

Top

References

  1. Madias NE, Cohen JJ: Respiratory acidosis, in Acid-Base edited by Cohen JJ, Kassirer JP, Boston, Little, Brown, 1982, pp 307–348
  2. Gennari FJ, Kassirer JP: Respiratory alkalosis, in Acid-Base, edited by CCohen JJ, Kassirer JP, Boston, Little, Brown, 1982, pp 349–376
  3. Cohen JJ, Madias NE, Wolf CJ, Schwartz WB: Regulation of acid base equilibrium in chronic hypocapnia: Evidence that the response of the kidney is not geared to the defense of extracellular [H+]. J Clin Invest 578:1483, 1976
  4. Madias NE, Schwartz WB, Cohen JJ: The maladaptive renal response to secondary hypocapnia during chronic HC1 acidosis in the dog. J Clin Invest 60:1393, 1977
  5. Madias NE, Adrogué HJ, Cohen JJ: Maladaptive renal response to secondary hypocapnia in chronic metabolic alkalosis. Am J Physiol 238:F283, 1980
  6. Madias NE, Wolf CJ, Cohen JJ: Regulation of acid-base equilibrium in chronic hypercapnia. Kidney Int 27:538–543, 1985 | Article |
  7. Madias NE, Adrogué HJ, Cohen JJ, Schwartz WB: Effect of natural variations in PaCO2 on plasma [HCO3-] in dogs: a redefinition of normal. Am J Physiol (Renal Fluid Electrolyte Physiol) 5:F30–F35, 1979
  8. Madias NE, Adrogué HJ, Horowitz GL, Cohen JJ, Schwartz WB: A redefinition of normal acid-base equilibrium in man: Carbon dioxide tension as a key determination of normal plasma bicarbonate concentration. Kidney Int 16:612–618, 1979
  9. Schwartz WB, Brackett WC Jr, Cohen JJ: The response of extracellular hydrogen ion concentration to graded degrees of chronic hypercapnia: the physiologic limits of the defense of pH. J Clin Invest 44:291–301, 1965
  10. Alpern RJ, Warnock DG, Rector FC Jr: Renal acidification mechanisms (chapter 7), in The Kidney (3rd ed), edited by Brenner BM, Rector FC Jr, Saunders, in press
  11. Aronson PS: Mechanisms of active H+ secretion in the proximal tubule. Am J Physiol 245:647–659, 1983
  12. Schwartz GJ, Al-Awqati Q: CO2 causes exocytosis of vesicles containing H+ pumps in isolated perfused proximal and collecting tubules. J Clin Invest 75:1638–1644, 1985 | PubMed | ISI | ChemPort |
  13. Alpern RJ: Mechanism of basolateral membrane HCO3 in the rat proximal convoluted tubule. Clin Res, in press
  14. Lombard WE, Kokko JP, Jacobson HR: Bicarbonate transport in cortical and outer medullary collecting tubules. Am J Physiol 244:F289–F296, 1983 | PubMed | ChemPort |
  15. Stone DK, Seldin DW, Kokko JP, Jacobson HR: Mineralocor-ticoid modulation of rabbit medullary collecting duct acidification: a sodium-independent effect. J Clin Invest 72:77–83, 1983 | PubMed | ChemPort |
  16. Gluck S, Al-Awqati Q: An electrogenic proton translocating ATPase from bovine kidney medulla. J Clin Invest 73:1704–1710, 1984 | PubMed | ISI | ChemPort |
  17. Ullrich KJ, Papavassiliou F: Bicarbonate reabsorption in the papillary collecting duct of rats. Pflügers Arch 289:271–275, 1981 | Article |
  18. Stone DK, Seldin DW, Kokko JP, Jacobson HR: Anion dependence of rabbit medullary collecting duct acidification. J Clin Invest 71:1505–1508, 1983
  19. Cohen LH, Mueller A, Steinmetz PR: Inhibition of the HCO3 exit step in urinary acidification by a disulfonic stilbene. J Clin Invest 61:981–986, 1978
  20. Fischer JL, Husted RF, Steinmetz PR: Chloride dependence of the HCO3 exit step in urinary acidification. Am J Physiol 245:F564–F568, 1983
  21. Schwartz GJ, Al-Awqati Q: Two functionally distinct types of mitochondria rich cells in cortical collecting tubules as determined by changes in cell pH in individually identified cells. Kidney Int 27:190A, 1985
  22. Steinmetz PR: Cellular mechanism of urinary acidification. Physiol Rev 54:890–956, 1974 | PubMed | ISI | ChemPort |
  23. Leslie BR, Schwartz JH, Steinmetz PR: Coupling between CI absorption and HCO3 secretion in turtle urinary bladder. Am J Physiol 225:610–617, 1973
  24. Oliver JA, Himmelstein S, Steinmetz PR: Energy dependence of urinary HCO3 secretion in turtle bladder. J Clin Invest 55:1003–1008, 1975
  25. McKinney TD, Burg MB: Bicarbonate secretion by rabbit cortical collecting tubules in vitro. J Clin Invest 61:1421–1424, 1978
  26. Garcia-Austt J, Good DW, Burg M, Knepper MA: Unidirectional bicarbonate fluxes in cortical collecting ducts of deoxycorticosterone treated rabbits. Kidney Int 27:282, 1985
  27. Dixon TE, Al-Awqati Q: Urinary acidification in the turtle bladder is due to a reversible proton translocating ATPase. Proc Natl Acad Sci USA 76:3135–3138, 1979 | Article |
  28. Gluck S, Kelly S, Al-Awqati Q: The proton translocating ATPase responsible for urinary acidification. J Biol Chem 275:9230–9233, 1982
  29. Stone DK, Xie X-S, Racker E: An ATP driven proton pump inclathrin-coated vesicles. J Biol Chem 258:4059–5062, 1983 | PubMed | ISI | ChemPort |
  30. Galloway CJ, Dean GE, Marsh M, Rudnick MG, Mellman I: Acidification of macrophage and fibroblast endocytic vesicles in vitro. Proc Natl Acad Sci USA 80:3334–3338, 1983 | PubMed | ChemPort |
  31. Forgac N, Cantley L, Wiedemann B, Altstiel L, Branton D: Clathrin-coated vesicles contain an ATP-dependent proton pump. Proc Natl Acad Sci USA 80:1300–1303, 1983 | Article |
  32. Glickman J, Croen K, Kelly S, Al-Awqati Q: Golgi membranes contain an electrogenic H+ pump in parallel with a chloride conductance. J Cell Biol 97:1303–1308, 1983 | Article | PubMed | ISI | ChemPort |
  33. Rees-Jones R, Al-Awqati Q: Proton-translocating adenosinetri-phosphatase in rough and smooth microsomes from rat liver. Biochemistry 23:2236–2240, 1984 | Article | PubMed | ChemPort |
  34. Al-Awqati Q, Mueller A, Steinmetz PR: Transport of H+ against electrochemical gradients in turtle urinary bladder. Am J Physiol 223:F502–F508, 1977
  35. Al-Awqati Q, Norby L, Mueller A, Steinmetz PR: Characteristics of stimulation of H+ transport by aldosterone in turtle bladder. J Clin Invest 58:351–358, 1976
  36. Gluck S, Cannon C, Al-Awqati Q: Exocytosis regulates H+ transport in the turtle bladder by rapid insertion of H+ pumps into the luminal membrane. Proc Natl Acad Sci USA 79:4327–4331, 1982 | Article | PubMed | ChemPort |
  37. Al-Awqati Q, Gluck S, Reeves W, Cannon C: Regulation of proton transport in urinary epithelia. J Exp Biol 106:135–141, 1983
  38. Cannon C, van Adelsberg J, Kelly S, Al-Awqati Q: Carbon dioxide-induced exocytotic insertion of H+ pump in turtle bladder luminal membrane: role of cell pH and calcium. Nature 314:443–446, 1985 | Article | PubMed | ISI | ChemPort |
  39. Rodman JS, Kerjaschki D, Merisko E, Farquhar MG: Presence of an extensive clathrin coat on the apical plasma lemma of the rat kidney proximal tubule. J Cell Biol 98:1630–1636, 1984 | Article | PubMed | ChemPort |
  40. Lorentzen M, Taylor A, Windhager EE: pH effect on osmotic response of collecting tubules to vasopressin and 8CPT-cAMP. Am J Physiol 245:F188–F197, 1983
  41. Schwartz GJ, Al-Awqati Q: Polarity of H+ transport in the two types of mitochondria-rich cell of cortical collecting tubule. Clin Res, in press
  42. Cogan MG, Rector FC Jr: Acid-base disorders (chapter 13), in The Kidney (3rd ed), edited by Brenner BM, Rector FC, Jr, Saunders, in press
  43. Aronson PS, Nee J, Suhm HA: Modifier role of internal H+ in activating the Na:H exchanger in renal microvillous membrane vesicles. Nature 299:161–163, 1982 | Article | PubMed | ISI | ChemPort |
  44. Bank N, Aynedjian HS, Mutz BF: Quantitative contribution of H+ ATPase to proximal HCO3 reabsorption in normal rats (abstract). Kidney Int 25:271, 1984
  45. Polak A, Haynie GD, Hays RM, Schwartz WB: Effects of chronic hypercapnia on electrolyte and acid-base equilibrium. I. Adaptation. J Clin Invest 40:1223–1237, 1961
  46. van Ypersele de Strihou C, Gulyassy PF, Schwartz WB: Effects of chronic hypercapnia on electrolyte and acid-base equilibrium. III. Characteristics of the adaptive and recovery process as evaluated by provision of alkali. J Clin Invest 41:2246–2253, 1962
  47. van Goidsenhoven GMT, Gray OV, Price AV, Sandelson PH: The effect of prolonged administration of large doses of sodium bicarbonate in man. Clin Sci 13:383, 1954
  48. Harrington JT, Kassirer JP: Metabolic alkalosis, in Acid-Base, edited by Cohen JJ, Kassirer JP, Little, Brown, 1982, pp 244–245
  49. Schwartz JH: H+ current response to CO2 and carbonic anhy-drase inhibition in turtle bladder. Am J Physiol 231:565–572, 1976
  50. Adrogué JH, Tasby J, Suki WN: Intracellular pH in the control of the H+ pump: Evidence from CO2 studies in the isolated turtle bladder. Trans Assoc Am Physicians 95:135–144, 1982
  51. Mello Aires M, Malnic G: Peritubular pH and PCO2 in renal tubular acidification. Am J Physiol 228:1766–1774, 1975
  52. Jacobson HR: Effects of CO2 and acetazolamide on bicarbonate and fluid transport in rabbit proximal tubules. Am J Physiol 240:F54–F62, 1981
  53. Bengele HH, Graber ML, Alexander EA: Effect of respiratory acidosis on acidification by the medullary collecting duct. Am J Physiol 244:F89–F94, 1983
  54. Lombard WE, Jacobson HR, Kokko JP: Effect of in vivo and in vitro acid-base manipulations on collecting duct bicarbonate transport (abstract). Clin Res 28:535, 1980
  55. Lucci MS, Puccaco LR, Carter NW, DuBose TD: Evaluation of bicarbonate transport in rat distal tubule: effects of acid-base status. Am J Physiol 243:F335–F341, 1982
  56. Breyer MD, Kokko JP, Jacobson HR: Peritubular bicarbonate concentration but not PCO2 regulates acidification in the cortical collecting tubule (abstract). Proc Am Soc Nephrol 17:180, 1984
  57. Adrogué HJ, Stinebaugh BJ, Gougoux A, Lemieux G, Vinay P, Tam SC, Goldstein MB, Halperin ML: Decreased distal acidification in acute hypercapnia in the dog. Am J Physiol 244:F19–F27, 1983
  58. Cogan MG: Chronic hypercapnia stimulates proximal bicarbonate reabsorption in the rat. J Clin Invest 74:1942, 1984

Extra navigation

.
ADVERTISEMENT