Clinical Investigation

Kidney International (1985) 28, 193–197; doi:10.1038/ki.1985.140

Association of HLA-DRw8 and DQw3 with minimal change nephrotic syndrome in Japanese adults

Yutaka Kobayashi1, Xiang-Mei Chen1, Yoshiwuki Hiki1, Kazufumi Fujii1 and Noboru Kashiwagi1

1Departments of Medicine and Transplantation Immunology, School of Medicine, Kitasato University, Sagamihara, Japan

Correspondence: Dr Y Kobayashi, Department of Medicine, School of Medicine, Kitasato University, Sagamihara 228, Japan

Received 6 November 1984; Revised 21 January 1985.

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Abstract

Association of HLA-DRw8 and DQw3 with minimal change nephrotic syndrome in Japanese adults. The HLA systems of forty Japanese patients with adult-onset nephrotic syndrome and biopsy-proven minimal change were investigated HLA-DRw8 was found in 35% of the patients and HLA-DQw3 in 95%, compared to 12.6 and 63.1% of the control, respectively (DRw8: and Pc < 0.01, RR = 3.74; DQw3: Pc < 0.02, RR = 11.1). The phenotype frequencies of all but one HLA-DR antigens, DR4, DR5, DRw8, and DRw9 associating with DQw3, were observed to increase (patient vs. control: DR4, 65 vs. 41.4%; DR5, 10 vs. 4.3%; DRw9, 20 vs. 23%). These results suggest that HLA-DQw3 may be a primary genetic marker associated with a major susceptibility gene to adult-onset minimal change nephrotic syndrome in the Japanese population.

Association de HLA-DRw8 et DQw3 au syndrone néphrotique à lésions glomérulaires minimes chez des adultes japonais. Le système HLA de quarante malades japonais atteints de syndrome néphrotique apparu à l'âge adulte, et dû à des lésions glomérulaires minimes prouvées par la biopsie, a été étudié. HLA-DRw8 a été trouvé chez 35% des malades, et HLA-DQw3 chez 95%, par rapport à 12.6 et 63,1% chez les contrôles, respectivement (DRw8: Pc < 0,01, RR = 3,74; DQw3: Pc < 0,02, RR = 11,1.). Les fréquences phénotypiques de tous les antigènes HLA-DR sauf un, DR4, DR5, DRw8, et DRw9 s'associant à DQw3, ont été trouvées augmentées (malades par rapport aux contrôles: DR4, 65 contre 41,4%; DR5, 10 contre 4,3%; DRw9, 20 contre 23%). Ces résultats suggèrent que HLA-DQw3 pourrait être un marqueur génétique primitivement associé à une susceptibilité génétique majeure lors du syndrome néphrotique à lésions glomérulaires minimes apparu chez l'adulte japonais.

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