Laboratory Investigation

Kidney International (1985) 28, 140–145; doi:10.1038/ki.1985.133

Renal hemodynamics and glomerular morphology in repetitively pregnant aging rats

Christine Baylis and Helmut G Rennke

Department of Medicine, University of California, San Diego, California, USA, and Department of Pathology, Brigham and Womens Hospital, Boston, Massachusetts, USA

Correspondence: C Baylis, Department of Medicine, Division of Nephrology, V151, University of California, San Diego, California 92093 USA

Received 29 June 1984; Revised 11 January 1985.

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Abstract

Renal hemodynamics and glomerular morphology in repetitively pregnant aging rats. Measurements were made of renal and glomerular hemodynamics and glomerular morphology in repetitively pregnant and age-matched virgin female Munich-Wistar rats. Repetitive pregnancies and lactation provide a stimulus to chronic increases in glomerular filtration rate (GFR) and these rats were studied, by micropuncture, ~ 4 to 6 weeks after the end of the fifth gestation/lactation cycle. No differences were seen in GFR or renal plasma flow (RPF) rate nor in any of the determinants of single nephron filtration rate (SNGFR) in repetitively pregnant compared to virgin rats, although SNGFR itself was slightly but significantly elevated in repetitively pregnant rats. There was no evidence of systemic hypertension, proteinuria, or abnormal glomerular morphology in either group despite their advanced age (~ 42 to 46 weeks). Thus, the moderate chronic increase in GFR due to the stimulus of repetitive pregnancy and lactation does not lead to eventual deterioration in renal function or structural abnormalities.

Hémodynamique rénale et morphologie glomérulaire chez des rattes âgées en gestations répétées. Des mesures de l'hémodynamique rénale et glomérulaire et de la morphologie glomérulaire ont été effectuées chez des rattes Munich-Wistar avec gestations répétées et chez des rattes vierges d'âge apparié. Les gestations et lactation répétées constituent un stimulus d'élévations chroniques de GFR et ces rattes ont été étudiées par microponction ~ 4 à 6 semaines après la fin du cinquième cycle de gestation/lactation. Il n'a pas été vu de différences de GFR ou de debit plasmatique rénal (RPF), ni d'aucun des déterminants de SNGFR chez les rattes vierges, bien que SNGFR elle-même soit légèrement mais significativement élevée chez les rattes gestantes de façon répétée. Il n'y avait pas d'hypertension systémique, de protéinurie, ou de morphologie glomérulaire anormale dans aucun groupe malgré leur âge avancé (~ 42 to 46 semaines). Ainsi, l'augmentation chronique modérée de GFR due au stimulus des gestations et lactations répétées ne conduit pas à une détérioration de la fonction rénale ni à des anomalies structurelles éventuelles.

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