Clinical Investigation

Kidney International (1984) 25, 953–957; doi:10.1038/ki.1984.116

Strong association of HLA-DR2 and MT1 with idiopathic membranous nephropathy in Japan

Yoshiyuki Hiki1, Yutaka Kobayashi1, Ichiro Itoh1 and Noboru Kashiwagi1

1Department of Clinical Pathology, Internal Medicine, and Transplant Immunology, Kitasato University School of Medicine, Sagamihara, Japan

Correspondence: Dr Y Kobayashi, Department of Internal Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

Received 30 August 1983; Revised 9 January 1984.

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Abstract

Strong association of HLA-DR2 and MT1 with idiopathic membranous nephropathy in Japan. Fifty adult Japanese patients with biopsy-proven idiopathic membranous nephropathy (IMN) were typed for HLA-A, B, and DR antigens, and additional B cell alloantigens designated the MT system. The phenotype frequencies of HLA-DR2 (80.0 vs. 36.0%) and MT1 (96.0 vs. 49.5%) appeared to be significantly increased in the patient group when compared to those of a control. There were lower frequencies of DR4, DRw9, MT3, and MT4 in these particular patients. The decreases of MT3 and MT4 were statistically significant but those of DR4 and DRw9 were not. These results suggest that HLA-DR2 and MT1 antigens are related to the occurrence of IMN in the Japanese population.

Association étroite entre HLA-DR2 et MT1 et néphropathie extra-membraneuse idiopathique au Japon. Cinquante malades Japonais adultes atteints d'une néphropathie extramembraneuse idiopathique (IMN) histologiquement prouvée ont été typés pour les antigènes HLA-A, B, et DR, et pour les alloantigènes supplémentaires des cellules B, désignés le système MT. Les fréquences des phénotypes HLA-DR2 (80,0 contre 36,0%) et MT1 (96,0 contre 49,5%) sont apparues significativement plus grandes dans le groupe des malades par rapport à celles d'un groupe contrôle. Il y avait des fréquences de DR4, DRw9, MT3, et MT4 plus faibles chez ces malades particuliers. Les diminutions de MT3 et MT4 étaient significatives, mais non celles de DR4 et DRw9. Ces résultats suggèrent que les antigènes HLA-DR2 et MT1 sont reliés à la survenue d'une IMN dans la population Japonaise.

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References

  1. Dixon FJ, Feldman JD, Vazquez JJ: Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med 113:899–919, 1961 | Article | PubMed | ISI | ChemPort |
  2. Germuth FG Jr, Rodriguez E: Experimental animal diseases, in Immunopathology of the Renal Glomerulus. Immune Complex Deposit and Antibasement Membrane Disease, Boston, Little Brown & Co., 1973, pp 15–43
  3. Klouda PT, Manos J, Acheson EJ, Dyer PA, Goldby FS, Harris R, Lawler W, Mallick NP: Strong association between idiopathic membranous nephropathy and HLA-DRw3. Lancet 13:770–771, 1979
  4. Le Petit JC, Laurent B, Berthoux FC: HLA-DR3 and idiopathic membranous nephritis (IMN) association. Tissue Antigens 20:227–228, 1982
  5. Müller GA, Müller C, Liebau G, Kömpf J, Ising H, Wernet P: Strong association of idiopathic membranous nephropathy (IMN) with HLA-DR3 and MT-2 without involvement of HLA-B18 and no association to BfF1. Tissue Antigens 17:332–337, 1981
  6. Ehrenreich T, Churg J: Pathology of membranous nephropathy. Pathol Annu 3:145–186, 1968
  7. Kobayashi Y, Tateno S, Shigematsu H, Hiki Y: Prednisone treatment in non nephrotic patients with idiopathic membranous nephropathy. A prospective study. Nephron 30:210–219, 1982
  8. Mittal KK, Mickey MR, Singal DP, Terasaki PI: Serotyping for homotransplantation. XVIII. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation 6:913–927, 1968 | PubMed | ISI | ChemPort |
  9. Wener C, Klouda PT, Corréa MC, Vassalli P, Jeannet M: Isolation of B and T lymphocytes by nylon fiber columns. Tissue Antigens 9:227–229, 1977
  10. Baur MP, Danilovs JA: Population analysis of HLA-A, B, C, DR, and other genetic markers, in Histocompatibility Testing 1980, edited by Terasaki PI, Los Angeles, UCLA Tissue Typing Laboratory, 1980, pp 955–993
  11. Svejgaard A, Jersild C, Nielsen S, Bodmer WF: HLA antigens and Disease: Statistical and genetical considerations. Tissue Antigens 4:95–105, 1974 | PubMed | ISI | ChemPort |
  12. Garavoy MR: Idiopathic membranous glomerulonephritis: An HLA-associated disease, in Histocompatibility Testing 1980, edited by Terasaki PI, Los Angeles, UCLA Tissue Typing Laboratory, 1980, pp 673–680
  13. Tomura S, Kashiwabara H, Shishido H, Tsuchida H, Sakurai S, Miyajima T, Tsuji K, Takeuchi J: Strong association of idiopathic membranous nephropathy with HLA-DR2 and MT1 in Japanese. Nephron 36:242–245, 1984
  14. Sasazuki T, Kohno Y, Iwamoto I, Tanimura M: Association between an HLA haplotype and low responsiveness to tetanus toxoid in man. Nature 272:359–361, 1978 | Article | PubMed | ISI | ChemPort |
  15. Sasazuki T, Ohta N, Kaneoka R, Kojima S: Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man. J Exp Med 152:314s–318s, 1980 | PubMed | ChemPort |
  16. Sasazuki T, Kaneoka H, Tsuji K, Nose Y, Kashiwagi N, Kaneko T: HLA-D in Japan, in Histocompatibility Testing 1980, edited by Terasaki PI, Los Angeles, UCLA Tissue Typing Laboratory, 1980, pp 274–276
  17. Reinsmoen NL, Sasazuki T, Kaneoka H, Ohta N, Noreen HJ, Greenberg LJ, Kersey JH: Two distinct HLA-D specificities (DHO and Dw2) in linkage with HLA-DRw2 as defined in white and Japanese populations. Transplant Proc 10:789–791, 1978
  18. Sasazuki T, McMichael A, Payne R, McDevitt HO: HLA-D antigens in the Japanese population. Tissue Antigens 9:267–272, 1977 | PubMed | ChemPort |
  19. Kallenberg CGM, Van Der Voort-Beelen JM, D'Amaro J, The TH: Increased frequency of B8/DR3 in scleroderma and association of the haplotype with impaired cellular immune response. Clin Exp Immunol 43:478–485, 1981
  20. McCombs CC, Michalski JP: Lymphocyte abnormality associated with HLA-B8 in healthy young adults. J Exp Med 156:936–941, 1982 | Article | PubMed | ChemPort |
  21. Ooi BS, Ooi YM, Hsu A, Hurtubise PE: Diminished synthesis of immunoglobulin by peripheral lymphocytes of patients with idiopathic membranous glomerulonephropathy. J Clin Invest 65:789–797, 1980 | PubMed |
  22. Matsumoto K, Osakabe K, Katayama H, Yoshizawa N, Harada M, Hatano M: Cell-mediated immunity in idiopathic membranous nephropathy. Int Arch Allergy Appl Immunol 66:310–315, 1981
  23. Matsumoto K, Osakabe K, Hatano M: Impaired cell-mediated immunity in idiopathic membranous nephropathy mediated by suppressor cells. Clin Nephrol 20:213–214, 1983
  24. Sekiguchi S, Kreisler M, Omori K, Nakata S, Park MS, Jeannet M: 8wDRw6Y(6.3, Se6), in Histocompatibility Testing 1980, edited by Terasaki PI, Los Angeles, UCLA Tissue Typing Laboratory, 1980, pp 530–531
  25. Schackelford DA, Mann DL, van Rood JJ, Ferrara GB, Strominger JL: Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen. Proc Natl Acad Sci USA 78:4566–4570, 1981
  26. Hiki Y, Kobayashi Y, Tateno S, Sada M, Kashiwagi N: Strong association of HLA-DR4 with benign IgA nephropathy. Nephron 32:222–226, 1982 | PubMed | ISI | ChemPort |

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