Nephrology Forum

Kidney International (1983) 24, 113–123; doi:10.1038/ki.1983.133

Oncogenic hypophosphatemic osteomalacia

Presentation of the Forum is made possible by grants from Smith Kline & French Laboratories, CIBA Pharmaceutical Company, Geigy Pharmaceuticals, and Hoechst-Roussel Pharmaceuticals Inc.

Principal discussant: Zalman S Agus1

1University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Correspondence: Dr Z Agus, 860 Gates Building, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA

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References

  1. Agus ZS, Goldfarb S, Wasserstein A: Mineral metabolism in health and disease, in Contemporary Nephrology, edited by Klahr S, Massry SG, New York, Plenum, 1981, vol. 1
  2. Dousa TP, Kempson SA: Regulation of renal brush border membrane transport of phosphate. Miner Electrolyte Metab 7:113–121, 1982
  3. Agus ZS: Renal handling of phosphate, in Textbook of Nephrology, edited by Massry S, Glassock R, Baltimore, Williams and Wilkins, 1983
  4. Dominguez JH, Gray RW, Lemann J Jr: Dietary phosphate deprivation in women and men: Effects on mineral and acid balances, parathyroid hormone and the metabolism of 25-OH vitamin D. J Clin Endocrinol Metab 43:1056–1068, 1976 | PubMed | ISI | ChemPort |
  5. Kreusser WJ, Kurokawa K, Aznar E, Massry SG: Phosphate depletion: Effect on renal inorganic phosphorus and adenine nucleotides, urinary phosphate and calcium, and calcium balances. Miner Electrolyte Metab 1:30–42, 1978
  6. Bonjour JP, Troehler U, Preston C, Fleisch H: Parathyroid hormone and renal handling of phosphate: Effect of dietary phosphate and diphosphates. Am J Physiol 234:F497–F505, 1978
  7. Troehler U, Bonjour JP, Fleisch H: Inorganic phosphate homeostasis: Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. J Clin Invest 57:264–273, 1976
  8. Cheng L, Sacktor B: Sodium gradient-dependent phosphate transport in renal brush border membrane. J Biol Chem 256:1556–1564, 1981
  9. Hoffman N, Thees M, Kinne R: Phosphate transport by isolated renal brush border vesicles. Pfluegers Arch 362:147–156, 1976
  10. Evers H, Murer H, Kinne R: Effect of parathyrin on the transport properties of isolated renal brush border vesicles. Biochem J 172:49–56, 1978
  11. Stoll R, Kinne R, Murer H, Fleisch H, Bonjour JP: Phosphate transport by rat renal brush border membrane vesicles: Influences of dietary phosphate, thyroparathyroidectomy and 1,25-dihydroxy vitamin D. Pfluegers Arch 380:47–52, 1979
  12. Tenenhouse HS, Scriver CR, Vizel EJ: Alkaline phosphatase activity does not mediate phosphate transport in the renal-cortical brush border membrane. Biochem J 190:473–476, 1980
  13. Kempson SA, Colson-Otero G, Lise Ou S-Y, Turner ST, Dousa TP: Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat. J Clin Invest 67:1347–1360, 1981 | PubMed |
  14. Hammerman MR, Hruska KA: Cyclic AMP dependent protein phosphorylation in canine renal brush border membrane vesicles is associated with decreased phosphate transport. J Biol Chem 257:992–999, 1982
  15. Avioli R, Miller RA, Birge SJ: Characterization of phosphate uptake in isolated chick intestinal cells. Adv Exp Med Biol 128:399–404, 1980
  16. Levine BS, Brautbar N, Coburn JW: Does vitamin D affect the renal handling of calcium and phosphate? Miner Electrolyte Metab 1:295–302, 1978
  17. Puschett JB: Renal tubular effects of vitamin D and its metabolites. Adv Exp Med Biol 81:29–40, 1977 | PubMed |
  18. Popovtzer MM, Mehandru S, Saghafi D, Blum MS: Interactions between PTH, vitamin D metabolites and other factors in tubular reabsorption of phosphate. Adv Exp Med Biol 103:11–19, 1978
  19. Bonjour JP, Preston C, Fleisch H: Effect of 1,25-dihydroxy vitamin D3 on the renal handling of Pi in parathyroidectomized rats. J Clin Invest 60:1419–1428, 1977 | PubMed |
  20. Liang CT, Barnes J, Cheng L, Balakir R, Sacktor B: Effects of 1,25(OH)2D3 administered in vivo on phosphate uptake by isolated chick renal cells. Am J Physiol 6:312–318, 1982
  21. Rader JI, Baylink DJ, Hughes MR, Safilian EF, Haussler MR: Calcium and phosphate deficiency in rats: Effects on PTH and 1,25-dihydroxy vitamin D3. Am J Physiol 236:E118–E122, 1979 | PubMed | ISI | ChemPort |
  22. Eisman JA, Wark JD, Prince RL, Moseley JM: Modulation of plasma 1,25-dihydroxy vitamin D in man by stimulation and suppression tests. Lancet 2:931–933, 1979
  23. Brunette MG, Chan M, Ferriere C, Roberts KD: Site of 1,25(OH)D2 vitamin D3 synthesis in the kidney. Nature 276:287–289, 1978 | Article | PubMed | ISI | ChemPort |
  24. Kawashima H, Torikai S, Kurokawa K: Localization of 25 hydroxy vitamin D3 1alpha-hydroxylase and 24-hydroxylase along the rat nephron. Proc Natl Acad Sci USA 78:1199–1203, 1981 | Article | PubMed | ChemPort |
  25. Ritz E: Nephrology Forum: Acute hypophosphatemia. Kidney Int 22:84–94, 1982
  26. Albright F, Butler AM, Bloomberg E: Rickets resistant to vitamin D therapy. Am J Dis Child 54:529–536, 1937
  27. Falls WF Jr, Carter N, Rector FW, Seldin DW: Familial vitamin D resistant rickets: Study of six cases with evaluation of the pathogenic role of secondary hyperparathyroidism. Ann Intern Med 68:553–560, 1968
  28. Lyles KW, Clark AG, Drezner MK: Serum 1,25-dihydroxy vitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. Calcif Tissue Int 34:125–130, 1982 | PubMed | ISI | ChemPort |
  29. Chesney RW, Mazess RB, Rose P, Hamstra AJ, DeLuca HF: Supranormal 24-hydroxylase vitamin D and subnormal 1,25-dihydroxy vitamin D: their role in X-linked hypophosphatemic rickets. Am J Dis Child 134:140–143, 1980
  30. Scriver CR, Reade TM, DeLuca HF, Hamstra AJ: Serum 1,25-dihydroxy vitamin D levels in normal subjects and in patients with hereditary rickets or bone disease. N Engl J Med 299:976–979, 1982
  31. Lyles KW, Harrelson JM, Drezner MK: The efficacy of vitamin D2 and oral phosphate therapy in X-linked hypophosphatemic rickets and osteomalacia. J Clin Endocrinol Metab 54:307–315, 1982
  32. Eicher EM, Southard JL, Scriver CR, Glorieux FH: Mouse model for human familial hypophosphatemic (vitamin D resistant) rickets. Proc Natl Acad Sci USA 73:4667–4671, 1976 | Article | PubMed | ChemPort |
  33. Cowgill LD, Goldfarb S, Lau K, Slatopolsky E, Agus ZS: Evidence for an intrinsic renal tubular defect in mice with genetic hypophosphatemic rickets. J Clin Invest 63:1203–1210, 1979 | PubMed | ChemPort |
  34. Tenenhouse HS, Scriver CR, McInnes RR, Glorieux FH: Renal handling of phosphate in vivo and in vitro by the X-linked hypophosphatemic male mouse: Evidence for a defect in the brush border membrane. Kidney Int 14:230–244, 1978
  35. Meyer RA, Gray RW, Meyer MH: Abnormal vitamin D metabolism in the X-linked hypophosphatemic mouse. Endocrinology 107:1577–1581, 1980 | PubMed | ChemPort |
  36. Lobaugh B, Drezner MK: Abnormal regulation of renal 25-hydroxy vitamin D-1-alpha-hydroxylase activity in the X-linked hypophosphatemic mouse. J Clin Invest 71:400–403, 1983 | PubMed | ISI | ChemPort |
  37. Lyles KW, Drezner MK: Parathyroid hormone effects on serum 1,25-dihydroxy vitamin D levels in patients with X-linked hypophosphatemic rickets: Evidence for abnormal 25-hydroxy vitamin D-1alpha-hydroxylase activity. J Clin Endocrinol Metab 54:638–644, 1982
  38. McCance RA: Osteomalacia with Looser's nodes (milkman's syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years. Q J Med 16:33–46, 1947
  39. Dent CE, Stamp TCB: Hypophosphatemic osteomalacia presenting in adults. Q J Med 40:303–329, 1971
  40. Salassa RM, Jowsey J, Arnaud CD: Hypophosphatemic osteomalacia associated with "nonendocrine" tumors. N Engl J Med 283:65–70, 1970
  41. Dent CE, Friedman M: Hypophosphatemic osteomalacia with complete recovery. Br Med J 1:1676–1679, 1964
  42. Evans DJ, Azzopardi JG: Distinctive tumors of bone and soft tissue causing acquired vitamin D-resistant osteomalacia. Lancet 1:353–354, 1972
  43. Drezner MK, Feinglos MN: Osteomalacia due to 1alpha,25-dihydroxy cholecalciferol deficiency: Association with a giant cell tumor of bone. J Clin Invest 60:1046–1053, 1977 | PubMed | ISI | ChemPort |
  44. Lyles KW, Berry WR, Haussler M, Harrelson JM, Drezner MK: Hypophosphatemic osteomalacia: Association with prostatic carcinoma. Ann Intern Med 93:275–278, 1980
  45. Sweet RA, Males JL, Hamstra AJ, DeLuca HF: Vitamin D metabolite levels in oncogenic osteomalacia. Ann Intern Med 93:279–280, 1980 | PubMed | ISI | ChemPort |
  46. Aschinberg LC, Solomon LM, Zeis PM, Justice P, Rosenthal IM: Vitamin D resistant rickets associated with epidermal nevus syndrome: Demonstration of a phosphaturic substance in the dermal lesions. J Pediatr 91:56–60, 1977 | PubMed | ISI | ChemPort |
  47. Popovtzer MM: Tumor-induced hypophosphatemic osteomalacia: Evidence for a phosphaturic cyclic AMP-independent action of tumor extract. Clin Res 21:418A, 1981
  48. Lau K, Stom MC, Goldberg M, Goldfarb S, Gray RW, Lemann J Jr, Agus ZS: Evidence for a humoral phosphaturic factor in oncogenic hypophosphatemic osteomalacia. Clin Res 27:421A, 1979
  49. Lyles KW, Lobaugh B, Paulson DF, Drezner MK: Heterotransplantation of prostatic cancer from an affected patient creates an animal model for tumor-induced osteomalacia in the athymic nude mouse. Calcif Tiss Int 34:5–33, 1982
  50. Brewer ED, Tsai HC, Morris RC: Evidence for impairment of metabolism of 25-hydroxy vitamin D3 in children with Fanconi syndrome. Clin Res 24:154A, 1976
  51. Lau Y-K, Wasserstein A, Westby GR, Bosanac P, Grabie M, Mitnick P, Slatopolsky E, Goldfarb S, Agus ZS: Proximal tubular defects in idiopathic hypercalciuria: Resistance to phosphate administration. Miner Electrolyte Metab 7:237–249, 1982 | PubMed | ISI | ChemPort |
  52. Brickman AJ, Coburn JW, Kurokawa K, Bethune JE, Harrison H, Norman AW: Action of 1,25 dihydroxy cholecalciferol in patients with hypophosphatemic vitamin D-resistant rickets. N Engl J Med 289:495–498, 1973
  53. Russell RCG, Smith R, Preston C, Walton RJ, Woods CG, Henderson RG, Norman AW: The effect of 1,25-dihydroxy cholecalciferol on renal tubular reabsorption of phosphate, intestinal absorption of calcium, and bone histology in hypophosphatemic renal tubular rickets. Clin Sci Mol Med 48:177–186, 1975
  54. Drezner MK, Lyles KW, Haussler MR, Hazelton JM: Evaluation of a role for 1,25-dihydroxy vitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia. J Clin Invest 66:1020–1032, 1980
  55. Scriver CR, MacDonald W, Reade T, Glorieux FH, Norgrady B: Hypophosphatemic nonrachitic bone disease: An entity distinct from X-linked hypophosphatemia in the renal defect, bone involvement and inheritance. Am J Med Genet 1:101–117, 1977 | Article | PubMed | ISI | ChemPort |
  56. Bonjour JP, Caverzasio J, Fleisch H, Muhlbauer R, Troehler U: The adaptive system of the tubular transport of phosphate. Adv Exp Med Biol 151:1–12, 1982 | PubMed | ISI | ChemPort |
  57. Brazy PC, McKeown JW, Harris RH, Dennis VW: Comparative effects of dietary phosphate, unilateral nephrectomy and parathyroid hormone on phosphate transport by the rabbit proximal tubule. Kidney Int 17:788–800, 1980
  58. Albright FP, Henneman P, Benedict P, Forbes AP: Idiopathic hypercalciuria. Proc R Soc Med 46:1077–1081, 1953 | PubMed | ISI | ChemPort |
  59. Caldas AE, Gray RW, Lemann J Jr: The simultaneous measurement of vitamin D metabolites in plasma: Studies in healthy adults and in patients with calcium nephrolithiasis. J Lab Clin Med 91:840–849, 1978 | PubMed | ISI | ChemPort |
  60. Shen FH, Baylink DJ, Nielson RL, Sherrard DJ, Ivey JL, Haussler MR: Increased 1,25-dihydroxyvitamin D in idiopathic hypercalciuria. J Lab Clin Med 90:955–962, 1977 | PubMed | ISI | ChemPort |
  61. Sutton RAL, Walker VR: Responses to hydrochlorothiazide and acetazolamide in patients with calcium stones: Evidence suggesting a defect in renal tubular function. N Engl J Med 302:709–713, 1980
  62. Burckhardt P, Jaeger P: Secondary hyperparathyroidism in idiopathic renal hypercalciuria: Fact or theory. J Clin Endocrinol Metab 53:550–555, 1981
  63. Coe FL, Favus MJ, Crockett T, Strauss AL, Parks JH, Porat A, Gantt CL, Sherwood LM: Effects of low calcium diet on urine calcium excretion, parathyroid function and serum 1,25(OH)2D3 levels in patients with idiopathic hypercalciuria and in normal subjects. Am J Med 72:25–32, 1982 | Article | PubMed | ISI | ChemPort |
  64. Coe FL, Canterbury JM, Firpo JJ, Reiss E: Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria. J Clin Invest 52:134–142, 1973 | PubMed | ChemPort |
  65. Lau K, Eby B: Tubular mechanisms for the phosphaturic effects of NH4Cl administration. Kidney Int 19:109, 1981
  66. Kempson SA: Effect of metabolic acidosis on renal brush border membrane adaptation to low phosphorus diet. Kidney Int 22:225–233, 1982 | PubMed |
  67. Turner ST, Haugen TA, Dousa TP: Mechanism of phosphaturia induced by glucocorticoids in rats adapted to low phosphate diet. Clin Res 29:556A, 1981
  68. Eby B, Lau K: Effects of glucagon on tubular PO4 transport: Contrast with nicotinamide. Kidney Int 21:132, 1982
  69. Jubiz W, Haussler MR, McCain TA, Tolman KG: Plasma 1,25-dihydroxy-vitamin D levels in patients receiving anticonvulsant drugs. J Clin Endocrinol Metab 44:617–621, 1977 | PubMed | ChemPort |
  70. Wark JD, Larkins RG, Perry-Kune D, Peter CT, Ross DL, Sloman JG: Chronic diphenylhydantoin therapy does not reduce plasma 25-hydroxyvitamin D. Clin Endocrinol 11:267–274, 1979
  71. Harrison HC, Harrison HE: Inhibition of vitamin D stimulated active transport of calcium of rat intestine by diphenylhydantoin phenobarbital treatment. Proc Soc Exp Biol Med 153:220–224, 1976
  72. Hahn TJ, Scharp CR, Richardson CA, Halstead LR, Kahn AJ, Teitelbaum SL: Interaction of diphenylhydantoin and phenobarbital with hormonal mediation of fetal rat bone resorption in vitro. J Clin Invest 62:406–414, 1978 | PubMed | ISI | ChemPort |
  73. Hahn TJ, Squires AE, Halstead LR, Stromingen DB: Reduced serum 25-hydroxyvitamin D concentration and disordered mineral metabolism in patients with cystic fibrosis. J Pediatr 94:38–42, 1979
  74. Kukumoto Y, Tarui S, Tsukiyama K, Ichihara K, Moriwaki K, Nonaka K, Mizushima T, Kobayashi Y, Bokoh S, Fukunaga M, Morita R: Tumor-induced vitamin D-resistant hypophosphatemic osteomalacia associated with proximal renal tubular dysfunction and 1,25-dihydroxyvitamin D deficiency. J Clin Endocrinol Metab 49:873–878, 1979
  75. Brunette MG, Chabardes D, Imbert-Teboul M, Clique A, Montegut M, Morel F: Hormone sensitive adenylate cyclase activity along the nephron of genetically hypophosphatemic mice. Kidney Int 15:357–369, 1979

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