Editorial Review

Kidney International (1981) 20, 543–548; doi:10.1038/ki.1981.175

An hypothesis to explain the ultrafiltration characteristics of peritoneal dialysis

Karl D Nolph1, Frederick N Miller1, W Keith Pyle1, Robert P Popovich1 and Michael I Sorkin1

1Columbia, Missouri and Austin, Texas

Correspondence: Dr K D Nolph, Division of Nephrology, Department of Medicine, University of Missouri Medical Center, M472 Medical Center, Columbia, Missouri 65212, USA

Received 9 July 1980; Revised 2 March 1981.

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Abstract

Net removal of fluid and sodium from the body during peritoneal dialysis is accomplished with dialysis solutions that contain high glucose concentrations and are hyperosmolar to body fluid [1]. Commercially available peritoneal dialysis solutions contain glucose concentrations ranging from 1.5 to 4.25 g/dl and have osmolalities ranging from 334 to 490 mOsm/kg H2O. The solutions also contain concentrations of sodium, chloride, magnesium, and calcium that approach those of normal extracellular fluid. Acetate or lactate, rather than bicarbonate, is used as the nonchloride anion. Potassium may be added or, depending on the need for potassium removal, solutions may be potassium-free.

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References

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